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优化重症肺炎病人给药方案的药学服务

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摘要 碳青霉烯类抗生素是目前临床治疗产超广谱β-内酰胺酶(extended spectrumβ-lactamases,ESBLs)及AmpC酶等多重耐药菌株所引起感染的最有效的抗菌药物。美罗培南为第二代碳青霉烯类抗生素,与第一代碳青霉烯类抗生素亚胺培南相比,美罗培南在C1位点有一个甲基,可增强对肾脱氢肽酶21(dehydropeptidase-21,DHP-21)的稳定性,不需要与酶抑制剂合用,安全性较高;在C2位点有二甲基氨酰基吡咯烷硫键,可增加对G^-菌的抗菌活性。
作者 査娴 方洁
出处 《药学服务与研究》 CAS 2015年第6期470-472,共3页 Pharmaceutical Care and Research
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参考文献9

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