血清β2-微球蛋白与脑梗死神经功能缺损程度及近期预后关系的研究

The relationship between the serum beta2-microglobulin and cerebral infraction and its severity and recent prognosis

目的探讨血清β2-微球蛋白(β2-microglobulin,β2-MG)与急性脑梗死的发病、病情严重程度及近期预后的关系。方法选取急性脑梗死患者150例为病例组,测定入院时β2-MG、NIHSS评分,按照NHISS评分分为轻、中、重3组,治疗10 d后按照NIHSS评分减少百分数分为基本痊愈组、显著进步组、进步组、无变化+恶化组,选取同期健康体检者50例为对照组,分析病例组与对照组之间、脑梗死各组之间血清β2-MG差异。结果急性脑梗死患者血清β2-MG水平明显高于对照组,差异有统计学意义(P<0.05);轻、中、重型脑梗死组之间血清β2-MG水平有差异性,其浓度随NIHSS评分增加而升高,以重型组升高最明显,差异有统计学意义(P<0.05);Logistic线性回归分析后发现脑梗死患者血清β2-MG与入院时NIHSS评分正相关(r=0.956,P=0.001);急性脑梗死血清β2-MG在不同预后组之间具有差异性,基本痊愈组水平明显低于其他各组,差异有统计学意义(P<0.05)。结论急性脑梗死患者血清β2-MG可能为脑梗死独立的危险因素,可作为评价病情严重程度及近期预后的一项指标。

Objective To investigate the relationship between serum beta2-microglobulin （β2-MG） and the severity, recent prognosis of acute cerebral infarction. Methods The investment contained 150 acute cerebral infraction patients and 50 controls, the patients were classified into three groups according to NIHSS scores. After 10 days, treatment, patients were classified into four group according to the NIHSS score reduction percentage including basic recovery group, remarkable progress group,the progress group, no change and worse group. Analyse the differences of serum β2-MG between the patients and controls,and the differences among different cerebral infarction groups. Results The serum β2-MG of patients was significant higher than the controls （ P 〈 0.05 ）, it elevated with the severity of acute cerebral infarction according to NIHSS. Logistic linear analysis finds that the serum β2-MG was related with NIHSS scores （r = 0. 956, P = 0.001 ）. The serum β2-MG has a significant difference among basic recovery group, remarkable progress group, the progress group and no change ＋ worse group （ P 〈 0.05 ）, and the basic level of recovery group was the lowerest （ P 〈 0.05 ）. Conclusion The serum β2-MG may be an independent risk factors of acute cerebral infarction, it could be used as an indicator of the severity and recent prognosis of acute cerebral infraction.