生长抑素对急诊腹部损伤患者术后胃肠功能恢复的临床观察

The Role of Somatostatin in Gastrointestinal Function after Operation for Treatment of Abdominal Injury

目的探讨生长抑素对腹部损伤患者术后胃肠功能恢复的治疗作用。方法回顾性分析笔者所在医院急救中心创伤外科2012年4月至2014年8月期间收治的60例急诊腹部损伤患者的临床资料,其中30例术后给予生长抑素治疗(治疗组),另外30例术后未应用生长抑素治疗(对照组),观察2组患者手术后胃肠减压引流量、肠鸣音恢复时间、肛门排气排便时间以及C反应蛋白、血清TNF-α、IL-6和IL-8水平的变化。结果治疗组患者肠鸣音恢复时间和肛门排气排便时间均较对照组早、住院时间缩短、胃肠减压引流量减少(P<0.05);血清C反应蛋白、TNF-α、IL-6和IL-8水平低于对照组(P<0.05),且各指标术后的下降幅度治疗组大于对照组(P<0.05)。结论腹部外伤患者术后应用生长抑素能促进胃肠功能的恢复。

Objective To investigate the role of somatostatin in gastrointestinal function after operation for treat- ment of abdominal injury patients. Methods Sixty patients with abdominal trauma were divided into somatostatin in treatment group （n=30） and the conventional treatment control group （n=30）. The amount of gastrointestinal decompre- ssion drainage, bowel sounds recovery time, exhaust time, defecation time, and the levels of serum C reactive protein, TNF-α, IL-6, and IL-8 after operation in two groups were observed. Results Somatostatin treatment group recovery time of bowel sounds, exhaust time, and defecation time were earlier than the control group, hospitalization time shortened, and the amount of gastrointestinal decompression drainage reduced （P〈0.05）, The levels of serum C reactive protein, TNF-α IL-6 and IL-8 of somatostatin treatment group were lower than those in control group （P〈0.05）, and the magnitude of decline above index in the somatostatin treatment group were greater than that in the control group （P〈0.05）. Conclusion Somatostatin can promote the recovery of gastrointestinal function in patients after operation in abdominal injury.