肝内胆管细胞癌预后因子的研究进展

The Advance of Intrahepatic Cholangiocarcinoma Prognostic Factors

目的 综述目前能够判断肝内胆管细胞癌预后的各种分子生物学指标,以期促进肝内胆管细胞癌患者后续治疗的制定与开展,提高患者的生存率和生存质量。方法 应用Pub Med及CNKI期刊全文数据库检索系统,以“肝内胆管细胞癌”及“预后”为关键词,检索2000~2015年期间的相关文献,共检索到英文文献48篇和中文文献15篇。纳入标准为：影响肝内胆管细胞癌患者预后的生物学指标,能够有效指导后期治疗。根据纳入标准,纳入45篇文献。结果 Homer1、黏蛋白-1（MUC1）/黏蛋白-4（MUC4）、乳酸脱氢酶A（LDH-A）、自噬基因Beclin1、Smad4、酪氨酸激酶-7（PTK7）、IMP3、细胞角蛋白7（CK7）/细胞角蛋白20（CK20）和鞘氨醇激酶1（SPHK1）这些指标可以作为预后因子,在肝内胆管细胞癌患者生存分析及判断肿瘤大小和分期、血管侵袭、神经损伤及淋巴结转移上均具有重要的临床意义。结论 Homer1、MUC1／MUC4、LDH-A、Beclin1、Smad4、PTK7、IMP3、CK7/CK20和SPHK1这些指标在判断肝内胆管细胞癌的预后及对于后续治疗做出相应调整都具有重要的意义。

Objective To overview the various molecular biological index to judge the prognosis of intrahepatic cholangiocarcinoma （ICC）, in order to promote ICC patients follow-up treatment, improve survival rate, and quality of life of the patients. Methods ＂ICC＂ and ＂prognostic factor＂ were searched as key words by PubMed and CNKI series full-text database retrieval systems from 2000 to 2015. Totally 48 English papers and 15 Chinese papers were obtained. Choice criteria： the molecular biological index that affect the prognosis of ICC patients, and can effectively guide treatment. According to the choice criteria, 45 papers were finally analyzed. Results The indicators of Homer1, mucin 1 （MUC1）／mucin 4 （MUC4）, lactate dehydrogenase A （LDH-A）, Beclinl, Smad4, protein tyrosine kinase-7 （PTK7）, IMP3, cytokeratin 7 （CK7）/cytokeratin 20 （CK20）, and sphingosine kinase 1 （SPHK1） could be used as prognostic factors in the survival of patients with ICC, and to determine tumor size and stage, vascular invasion, nerve injury, and lymph node metastasis, are of great clinical significance. Conclusion These indicators have a significant meanning in the prognosis of ICC and the adjustment of the follow-up treatment.