提高肝癌肝移植疗效的综合策略

Comprehensive strategy for improving the outcome of liver transplantation in patients with hepatocellular carcinoma

肝移植作为治疗肝癌的根治性手段之一,为肝癌治疗带来了新的希望,但术后肿瘤复发转移已成为影响肝癌肝移植疗效的最主要因素。深入研究肝癌的生物学特性和肝移植术后患者的免疫状态与肿瘤复发转移的关系;筛选准确预测肝癌肝移植的预后指标;合理选择病例,并对高危复发风险的患者进行有效的干预治疗;积极控制原发性疾病;以及复发转移后的个体化治疗等综合策略将有助于进一步提高肝移植治疗肝癌的疗效。精准医疗时代,新的治疗手段及理念将改变治疗的策略。

As a radical treatment for hepatocellular carcinoma（ HCC）,liver transplantation（ LT） brings new hope for the treatment of HCC,but tumor recurrence and metastasis after LT remain the most important factor that affects the outcome of LT in HCC. The comprehensive strategy,including investigating the biological characteristics of HCC and the relationship between immune status after LT and tumor recurrence,selecting the factors which can accurately predict the prognosis after LT in HCC,screening the cases reasonably and providing effective intervention for patients at a high risk of recurrence,controlling the primary disease actively,and providing individualized treatment for recurrence and metastasis,may further improve the outcome of LT in HCC. In the era of precision medicine,innovative treatments will change the strategies for treatment.