原发性胆汁性肝硬化危险因素的研究进展

Research advances in risk factors for primary biliary cirrhosis

原发性胆汁性肝硬化(PBC)是一种缓慢进行的自身免疫性肝病,其发病机制尚不明确。通过谷歌学术搜索与筛选,共获得29篇从不同角度报道PBC危险因素的文献,包括19篇评论、综述性文献和10篇调查研究。汇总10篇调查研究文献的研究对象和方法,以及所有纳入文献的结论,阐述危险因素对PBC的诱导机制,并提出了PBC的防治策略。由于所选文献均源自国外学者对国外人群的研究,因此这些结论在我国的适用性还有待进一步验证。

Primary biliary cirrhosis（ PBC） is an autoimmune liver disease which progresses slowly,and its pathogenesis remains unclear. A total of 29 papers reporting the risk factors for PBC from different perspectives were obtained through Google Scholar search and screening,consisting of 19 reviews and 10 reports of investigational studies. By summarizing the objects and methods in 10 investigational studies and the conclusions of all the 29 papers,the induction mechanism of risk factors for PBC is clarified,and the control strategy for PBC is put forward. Since the literature included was studies on foreign populations conducted by foreign scholars,the applicability of these findings in China should be further investigated.