摘要
目的:本研究尝试采用3D UTE成像及双指数T2*衰减模型分离骨皮质结合水和自由水。方法:在3T Skyra下对6例成年牛胫骨中段标本进行3D UTE成像,构建UTE双指数T2*衰减模型,对6例牛骨样本不同回波时间的UTE图像进行拟合,分别得到双指数拟合结果。结果:6例样本双指数拟合后,结合水(短)T2*=0.30ms,占比约81.6%,自由水(长)T2*=2.74ms,占比约18.4%。结论:3D UTE双指数衰减模型是一个有效的分离骨皮质结合水和自由水的方法,为定量评估骨质量提供了新的生物学指标,其对骨皮质结合水和自由水的分离有助于骨的力学性质的推断。
Purpose： This study attempted to use 3D UTE imaging with dual exponential T2＊ attenuation model for separating bound and free water in cortical bone. Methods： Six cases of adult bovine tibia were undergone 3D UTE imaging at 3T Skyra scanner, the dual exponential T2＊ relaxation model was constructed. UTE images of 6 bovine bone samples with different echo time were fitted in Matlab,and the fitted apparent bound and free water in cortical bone were obtained. Results： The average T2＊ values of bound and free water in bovine cortical bone fitted by the dual exponential fitting was 0.30 ms and 2.74 ms, accounted for approximately 81.6% and 18.4% in volume, respectively. Conclusion： 3D UTE with dual exponential decay model is an effective fitting method to separate the bound and free water in cortical bone, and provides a new biological indicator for quantitative bone quality, which can be potentially helpful to assess the mechanical properties of cortical bone.
出处
《中国医学计算机成像杂志》
CSCD
北大核心
2015年第6期591-595,共5页
Chinese Computed Medical Imaging
基金
上海市科委西医类引导项目(14411962700)
江苏省自然科学基金面上项目(BK20151293)~~
