阿卡波糖联合二甲双胍治疗2型糖尿病疗效观察

Acarbose combination with Metformin in the treatment of type 2 diabetes clinical observation

目的观察阿卡波糖联合二甲双胍治疗2型糖尿病的疗效及安全性。方法选择2013年1月—2014年9月我院就诊的确诊2型糖尿病患者66例,随机分为观察组及对照组,观察组阿卡波糖50 mg嚼服,3次/d,同时口服二甲双胍0.5 g,3次/d;对照组口服二甲双胍0.5 g,3次/d,疗程均为3个月。结果 1治疗3个月后2组患者空腹血糖(FBG)、餐后2 h血糖(2hP G)及糖化血红蛋白(Hb A1c)均较治疗前降低,但观察组较对照组下降更显著,差异具有统计学意义(P<0.05)。2观察组总有效率高于对照组,2组比较差异有统计学意义。32组仅有少数患者发生低血糖及胃肠道反应,均未影响治疗。结论阿卡波糖联合二甲双胍能有效地控制空腹及餐后血糖,安全性好,是超重、肥胖的2型糖尿病患者较为理想的联合治疗方法。

Objective Observation of acarbose combination with metformin efficacy and safety for the treatment of type 2 diabetes. Methods Choose in January 2013-September 2014 in Yu Ci People＇s Hospital confirmed 66 patients with type 2 diabetes,Randomly divided into observation group and control group,Observation group chewing acarbose 50 mg,3 times/day and Oral metformin 0.5 g,3 times/day,The control group oral metformin 0.5 g,3 times/day,reatment for3 months. Results 1After treatment three months,The control group and observation group with FBG,2h PG and Hb A1 c are lower than before treatment,But the observation group lower significantly,Compare the difference was statistically significant. 2 The observation group total effective rate was higher than the control group,Compare the difference was statistically significant. 3 Two groups of only a handful of cases of hypoglycemia and gastrointestinal reaction,all did not affect the treatment. Conclusions Acarbose combination with metformin can effectively control FBG and PPG,reduce the weight,excellent security,are overweight and obese patients with type 2 diabetes ideal combination therapy method.