生活方式、药物与人体血尿酸水平关系研究进展

Advance in Study of Relationship among Lifestyle, Drug and Human Serum Uric Acid Levels

尿酸是嘌呤代谢的最终产物，主要通过肾脏排出体外。人体血尿酸水平过高或过低都会造成一系列健康问题。流行病学研究显示，生活方式、药物可以影响血尿酸水平。本文综述了生活方式、药物与人体血尿酸水平关系的研究进展，显示酒精、超重或肥胖、高血压、低剂量阿司匹林、利尿剂是血尿酸水平升高的危险因素；坚持体力活动、高剂量阿司匹林是血尿酸水平升高的保护因素。

Uric acid is the end product of purine metabolism, primarily excreted through the kidney. Higher or lower human serum uric acid levels both can result in a series of health problems. Epidemiological studies have shown tbat lifestyle and drug influence levels of serum uric acid. This article reviews the association of lifestyle and drug with human serum uric acid levels. Researches show that alcohol, overweight or obese, hypertension, low-dose aspirin, diuretic are risk factors for high serum uric acid level while physical activity, high-dose aspirin are protective factors for high serum uric acid level.