碳青霉烯类耐药鲍氏不动杆菌定植与感染的危险因素分析

Risk factors for carbapenem-resistant acinetobacter baumannii colonization and infection in hospitalized patients

目的探讨碳青霉烯类耐药鲍氏不动杆菌定植与感染的住院患者的危险因素。方法分析了痰标本检出碳青霉烯类耐药的鲍氏不动杆菌定植或感染的住院患者135例,查阅患者的年龄、性别、意识、预后、白蛋白、CRP、APACHEⅱ分、CPIS评分等指标,分析其与患者在碳青霉烯类耐药的鲍氏不动杆菌感染或定植的状态时的关系。根据临床症状和实验室检查结果判断是否肺部感染或定植。结果本组资料显示,定植39例,感染96例,除性别和APACHEⅱ评分外,其它指标在定植和感染组之间,经统计学分析均有显著差异。结论高龄、低蛋白是导致感染的危险因素,CRP和CPIS评分是评价感染的良好指标。

Objective To investigate the risk factors of hospitalized patients with respiratory colonization and infection due to carbapenem-resistant acinetobacter baumannii（ CRAB）. Methods From Jan 2011 to Dec 2012,the clinical data（ age,gender,consciousness,albumin,APACHEⅱ score,CPIS score,CRP and prognosis） of 135 hospitalized patients were retrospectively investigated,and comparisons were made between patients with respiratory colonization and infection due to CRAB. We classified them as CRAB infection or incidental colonization on the basis of clinical presentation. Results There were 39 cses of colonization and 96 cases of infection. Except gender and APACHE ⅱ score,the other indicators showed significant differences between the two groups（ P〈0. 05）. Conclusion Elderly low albumin is a risk factor for infection,and CRP and CPIS score is a good indicator of infection.