布地奈德福莫特罗吸入治疗咳嗽变异性哮喘及患者EOS、IL-8、IL-10的表达

Effect of budesonide formoterol inhalation in the treatment of cough variant asthma patients and the expression of EOS,IL-8 and IL-10

目的研究布地奈德福莫特罗吸入治疗咳嗽变异性哮喘疗效及患者嗜酸性粒细胞（EOS）、IL-8、IL-10的表达。方法以我院2013年1月~2014年6月收治的咳嗽变异性哮喘患者86例为研究对象,另选取来我院体检的健康志愿者80例为对照组。对比两组EOS、中性粒细胞、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）的表达水平,研究组治疗后对比治疗前、治疗后以及停药4个月后OS、IL-8、IL-10的表达以及咳嗽症状评分与ACT哮喘评价。结果研究组中性粒细胞个数与对照组相比显著更多;研究组患者痰液中EOS、IL-8、IL-10的表达水平均显著高于对照组;研究组患者用药结束后痰液中EOS、IL-8、IL-10的水平显著降低,但在停药四个月后又明显升高,不过较治疗前依旧较低;研究组患者停药四个月后咳嗽症状评分显著低于治疗前,且ACT哮喘评价也显著高于治疗前,以上差异具有统计学意义（P〈0.05）。结论布地奈德福莫特罗吸入能有效降低患者EOS、IL-8、IL-10的水平,极大改善哮喘症状。

Objective To analyze the effect of budesonide formoterol inhalation in the treatment of cough variant asthma patients and the expression of EOS,IL-8 and IL-10. Methods From January 2013 to June 2014,86 patients with cough variant asthma were selected as the study group,and another 80 healthy volunteers were taken as the control group. The levels of polymorphonuclear cells and eosinophils,IL-8 and IL-10 were compared between the two groups before and after the treatment. The expression of EOS,IL-8 and IL-10 and cough symptom scores were detected before and 4 months after medication. Results The neutrophil cell number was significantly more in the study group than in the control group. The expression of sputum EOS,IL-8 and IL-10 were significantly higher in the study group than in the control group. After medication,the levels of EOS,IL-8 and IL-10 decreased significantly in the study group,but 4 months after stopping the drug they increased significantly,which were still lower than before. The score of cough symptom was significantly lower after the treatment than before,and ACT was also significantly higher（ P〈0. 05）. Conclusion Budesonide and formoterol atomization inhalation in the treatment of cough variant asthma patients can effectively reduce EOS,IL-8 and IL-10 levels,and greatly reduce the symptoms of patients with asthma.