哮喘和慢阻肺重叠综合征患者血清总IgE水平改变及其临床意义研究

Clinical value of serum total IgE in syndrome of asthma and COPD patients

目的哮喘和慢性阻塞性肺疾病重叠综合征（SAC）患者血清总IgE水平改变及其临床意义研究。方法连续性收录28例哮喘患者,40例慢阻肺患者和22例SAC患者,综合分析比较三组患者肺功能情况和血清总IgE水平差异。结果慢阻肺组和SAC组患者FEV1%pred水平明显低于哮喘组（P〈0.05）。哮喘组和SAC组患者吸入支气管舒张剂后FEV1改善值明显高于慢阻肺组（P〈0.05）。慢阻肺患者血清总IgE水平明显低于哮喘组和SAC组患者（P〈0.05）,而哮喘组明显高于SAC组（P〈0.05）。通过Pearson相关性分析可见三组患者血清总IgE水平均与吸烟指数呈负相关（P〈0.05）。而SAC组患者可见血清总IgE水平与FEV1改善值呈负相关（P〈0.05）。血清总IgE的AUC为0.577,95%CI为0.505~0.624。结论 SAC患者血清总IgE水平明显高于慢阻肺组,而低于哮喘组,血清总IgE水平对于SAC的诊断价值较低。

Objective To evaluate the clinical value of serum total IgE in syndrome of asthma and COPD patients. Methods The study selected 28 asthma patients as the group A,40 COPD patients as the group B and 22 SAC patients as the group C. Pulmonary function test and serum total IgE level were compared and analyzed among the three groups. Results The levels of FEV1% pred in COPD group and SAC group were significantly lower than asthma group（ P〈0. 05）. The level of serum total IgE in the COPD group was lower than that in the SAC group.Pearson correlation analysis showed that the level of serum total IgE in the three groups was negatively associated with smoking index（ P〈0. 05）,and the level of serum total IgE in the SAC group was negatively associated with FEV1（ P〈0. 05）. Conclusion The level of serum IgE in SAC patients is higher than COPD patients but lower than asthma patients,which shows low value for SAC diagnosis.