基于前列腺增生症临床病症特点的动物模型分析

Analysis of animal models of benign prostatic hyperplasia based on its clinical characteristics

目的:基于前列腺增生症临床病症特点分析相应动物模型。方法:文章通过梳理分析中西医前列腺增生的临床诊断标准及疗效标准,总结前列腺增生动物模型的特点及造模方法,比对临床相关症状及标准,对现有动物模型与临床病症的吻合情况进行分析探讨,进而提出相应动物模型的评价及改进方法。结果:前列腺增生造模方法较多,但缺少能反映前列腺增生临床病症特点、体现前列腺增生中西医病因的动物模型复制,为动物模型确立合理的量化标准是前列腺增生动物模型的发展方向。结论:前列腺增生动物模型的复制应更加贴近于临床病症特点,以能反映前列腺增生临床特征。

Objective：To analyse the corresponding animal models of benign prostatic hyperplasia（BPH） based on its clinical characteristics.Methods：Based on the clinical diagnosis and treatment standards of TCM and western medicine BPH,the paper collected the characteristics and methods of BPH animal models.With a reference to the clinical diagnosis and treatment standards,the paper analysed the consistency between the BPH animal models and its clinical characteristics,and then came up with a corresponding evaluation and improvement methods for BPH animal model.Results：There were many BPH animal models,but there were neither a BPH animal model well reflecting its clinical characteristics nor a BPH animal model well reflecting its pathogeny of traditional Chinese medicine and Western medicine.A reasonable quantitative criterion for the BPH animal model was regarded as a development direction for BPH animal models in the future.Conclusion：The BPH animal model should be established in accordance with its clinical characteristics as far as possible that would well reflect its BPH clinical characteristics.