血清HE4、SCC及CEA联合检测在肺癌诊断中的临床意义

Clinical significance of combined detection of serum HE4,SCC and CEA in diagnosing lung cancer

目的探讨血清中人附睾蛋白4(HE4)、鳞状细胞癌抗原(SCC)及癌胚抗原(CEA)联合检测在肺癌诊断中的临床意义。方法采用化学发光法检测142例肺癌患者及106例肺良性疾病患者血清中HE4水平,分析其表达的差异;同时检测鳞状细胞癌抗原(SCC)及癌胚抗原(CEA)水平,进行统计学分析,计算灵敏度及特异度。结果 142例肺癌患者血清中HE4及CEA水平明显高于106例肺良性疾病组,差异有统计学意义(P<0.05);其中肺鳞癌以SCC灵敏度最高,达到67.42%,肺腺癌以CEA灵敏度最高,到达69.24%。HE4、SCC与CEA联合检测可以提高肺癌诊断的灵敏度和特异度。结论 HE4是有价值的肺癌诊断的指标,SCC对鳞癌的诊断灵敏度最高,CEA对腺癌的诊断灵敏度最高。3种指标联合检测有助于提高肺癌的检出率。

Objective To investigate the clinical significance of the combined detection of serum human epididymis protein 4（HE4）,squamous cell carcinoma（SCC）antigen and carcinoembryonic antigen（CEA）in the diagnosis of lung cancer.MethodsThe serum HE4 level in 142 cases of lung cancer and 106 cases of benign lung diseases was detected by using the chemiluminescence method,its differences between the two groups were analyzed;meanwhile the SCC and CEA levels were detected.The statistical analysis was performed.The sensitivity and specificity were calculated.Results The serum HE4 and CEA levels in the lung cancer group was significantly higher than that in the benign lung disease group,the difference was statistically significant（P〈0.05）;in which the sensitivity of SCC for squamous cell lung cancer was highest and reached 67.42%,while which of CEA for lung adenocarcinoma was highest and reached 69.24%.the combined detection of HE4,SCC and CEA could increase the sensitivity and specificity for diagnosing lung cancer.Conclusion He4 is valuable for diagnosis of lung cancer,the diagnostic sensitivity of SCC for squamous cell carcinoma was the highest,CEA is the most sensitive to the diagnosis of adenocarcinoma.Combined detection of 3indicators to improve the detection rate of lung cancer.