SCC和CYFRA21-1在糖尿病肾病患者中含量升高的意义

Significance of increase of SCC and CYFRA21-1 levels in patients with diabetic nephropathy

目的探索血清鳞状细胞癌抗原(SCC)和细胞角蛋白19片段抗原21-1(CYFRA21-1)在糖尿病肾病患者中异常升高的临床意义。方法检测100例糖尿病肾病患者和100例健康体检者血清SCC、CYFRA21-1和肌酐。结果与健康对照组相比,糖尿病肾病组SCC、CYFRA21-1水平和肌酐均明显升高,以上差异均具有统计学意义(P<0.05)。在糖尿病肾病组中,尿微量清蛋白大于200mg/L组的SCC、CYFRA21-1数值高于尿微量清蛋白小于200mg/L组,差异具有统计学意义(P<0.05)。结论糖尿病肾病患者血清中SCC和CYFRA21-1异常升高具有临床意义。

Objective To explore the clinical significance of abnormal elevation of serum squamous cell carcinoma（SCC）antigen and cytokeratin 19 fragment antigen 21-1（CYFRA21-1）in the patients with diabetic nephropathy.Methods 100 patients with diabetic nephropathy were selected as the diabetic nephropathy group and 100 individuals undergoing healthy physical examination were selected as the control group.The serum levels of SCC,CYFRA21-1and creatinine were detected in the two groups.ResultsThe serum levels of SCC,CYFRA21-1and creatinine in the diabetic nephropathy group were significantly higher than those in the control group,the differences were statistically significant（P〈0.05）.In the diabetic nephropathy group,the serum levels of SCC and CYFRA21-1in the mAlb〉200mg/L group were significantly higher than those in the mAlb〈200mg/L group,the difference was statistically significant（P〈0.05）.Conclusion Abnormal increase of the serum SCC and CYFRA21-1levels in the patients with diabetic nephropathy has clinical significance.