外周血维生素D,IL-6水平评价结直肠癌转移预后的应用

Application of peripheral blood vitamin D and IL-6 levels in evaluating metastasis prognosis of colorectal cancer

目的研究外周血VD、IL-6评价结直肠癌转移预后的应用。方法病理学证实结直肠癌患者91例,检测外周血VD、IL-6和CEA水平;采用logistic拟合分析其对结直肠癌转移预后评估。结果结直肠癌患者转移组VD（6.63±3.90）低于非转移组（10.05±3.98）,P〈0.001;转移组IL-6水平为16.13（10.15～43.80）高于非转移组为8.25（4.66～12.15）,P〈0.001;转移组CEA为9.49（2.38～117.34）高于非转移组为2.31（1.42～5.91）,P〈0.001。CEA与转移ROC曲线AUC=0.693,P=0.002,灵敏度为71.05,特异度为64.15;VD、IL-6及CEA拟合ROC曲线AUC=0.824,P〈0.001,灵敏度为73.68%,特异度为83.25%。结论结直肠癌患者血清VD、IL-6水平与转移预后有关,结合肿瘤抗原检测可作为判断结直肠癌预后的新的、有效的生物学指标。

Objective To study the application of peripheral blood vitamin D（VD）and interleukin-6（IL-6）levels in the evaluation the metastasis prognosis of colorectal cancer.Methods 91 patients with pathologically confirmed colorectal cancer were detected peripheral blood VD,IL-6and CEA levels.The Logistic fitting analysis was used to evaluate metastasis prognosis of colorectal cancer.Results The VD level in the colorectal cancer metastases group was lower than that in the non-metastasis group[（6.63±3.90）vs.（10.05±3.98）,P〈0.001];the IL-6level in the colorectal cancer metastases group was 16.13（10.15-43.80）,which was higher than 8.25（4.66-12.15）in the non-metastasis group（P〈0.001）,the CEA level in the metastasis group was 9.49（2.38-117.34）,which was higher than 2.31（1.42-5.91）in the non-metastasis group（P〈0.001）.CEA and transfer ROC curve AUC=0.693,P=0.002,with the sensitivity of 71.05 and the specificity of 64.15;VD,IL-6and CEA fitting ROC curve AUC=0.824,P〈0.001,with the sensitivity of 73.68 and the specificity of 83.25.Conclusion The peripheral blood VD and IL-6levels in the patients with colorectal cancer are associated with metastasis prognosis,which combined with tumor antigen detection can be used as the novel and effective biological indicators for evaluating the prognosis of colorectal cancer.