基于神经电极形状参数的脑组织微动损伤仿真

Simulation of Brain Micromotion Induced Injury Based on Investigation of Neural Probe Geometry Parameters

为了预测脑组织微动损伤,采用数值仿真法,基于超黏弹性本构对神经电极-大脑组织模型进行数值仿真,分析了神经电极形状参数(过渡圆角、楔形角、厚度)对脑组织微动损伤的影响规律.结果表明:圆角半径为20μm时最大应变与损伤区域均控制在较小范围;楔形角取为70°可降低最大应变10.34%,减少损伤区域34.52%;电极厚度为15μm时损伤区域最小.

In order to predict micromotion induced injury,finite element（FE）models,utilizing hyper-viscoelastic constitutive equations,were developed to conduct a series of numerical simulations of the neural probe-brain model.The influences of neural probe geometry parameters（e.g.tip fillet,wedge angle,wall thickness）on micromotion induced brain injury were investigated.The results show that the fillet radius of20 micrometers keeps both the maximum strain and injury zone in a small region while the wedge angle of70 degree leads to a 10.34%reduction in the strain and a 34.52% reduction in the injury zone.The wall thickness of 15 micrometers generates the minimal injury zone.