红花黄色素在患者尿中排泄率的研究

Clinical Trials of Urine Excretion Rate of safflower yellow in patients

目的应用液相色谱法测定丹参注射液在冠心病心绞痛患者体内对注射用羟基红花黄色素A(HYSA)排泄的影响。方法将9例受试者随机分组,A组5例,B组4例,男2例,女7例,均在试验前一天不用药,统一清淡饮食,A组接受注射用红花黄色素100 mg/d,B组给予注射用红花黄色素100 mg/d+丹参注射液10 m L,次日早餐后2 h单次静滴,收集24 h内尿样,检测HYSA尿中的药物排泄率。结果 HYSA在A组平均尿中排泄率为(69.78±13.56)%,B组平均排泄率为(40.59±14.64)%,B组较A组低。结论联合用药可以减少HYSA的排泄,延长在体内驻留时间。

Objective Through an accurate and simple method for liquid chromatography, determination of effects of salvia miltiorrhiza injection in patients with angina pectoris of coronary heart disease of safflower yellow a excretion of injection. Methods Nine subjects were randomly divided into two groups. A group of 5 cases, B group of 4 cases. Only one male respectively, were not used medication before the day, unified light diet. A group was injected with safflower yellow pigment 100 mg for the same day, and the day B group was injected with safflower yellow 100 mg and salvia miltiorrhiza injection 10 m L. The next morning breakfast 2 hours after a single intravenous infusion, collected 24 hours urine samples, the detection of hydroxysafflor yellow A（HYSA）. Results The average excretion rate of A group was 69.78±13.56%, and the average excretion rate of B group was 40.59±14.64%, and the excretion rate of safflower yellow was decreased by B group. Conclusion The detection rate of HYSA in urine of patients with combined medication use was lower, combined medication can reduse the excretion of HYSA and extended dwell time in the body.