摘要
目的研究高剂量阿托伐他汀治疗颈动脉粥样硬化对患者血脂及颈动脉内膜厚度的影响。方法选取2014年2月-2015年2月期间就诊的96例颈动脉粥样硬化症患者,随机数字表法分为高剂量组(n=48)和低剂量组(n=48),所有患者均给予阿司匹林口服治疗,小剂量组加用阿托伐他汀20 mg/d,大剂量组加用阿托伐他汀40 mg/d,睡前口服,持续治疗1个月,比较两组患者治疗前后血脂(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、颈动脉内膜中层厚度(IMT)水平及斑块厚度差异。结果治疗前两组各指标比较差异无统计学意义(P〉0.05);高剂量组治疗后TC(2.64±0.75)mmol/L、TG(1.07±0.30)mmol/L、LDL-C(1.35±0.36)mmol/L、IMT(0.90±0.21)mm及斑块厚度(1.92±0.15)mm较治疗前显著下降,低剂量组治疗后TC(3.18±0.92)mmol/L、TG(1.41±0.34)mmol/L、LDL-C(2.71±0.41)mmol/L、IMT(1.09±0.34)mm及斑块厚度(2.37±0.23)mm较治疗前也明显下降,治疗后两组组间比较差异均有统计学意义(P〈0.05)。结论高剂量阿托伐他汀治疗颈动脉粥样硬化症疗效好,能显著改善患者血脂,降低颈动脉内膜厚度。
Objective To study the effect of high dose atorvastatin in the treatment of carotid atherosclerosis on blood lipid and carotid intima media thickness in patients. Methods 96 patients with carotid atherosclerosis who were treated in our hospital during February 2014 to February 2015 were studied. According to the random number table method, the patients were divided into high dose group(n = 48) and low dose group(n = 48). All patients were given aspirin oral administration for treatment. Low dose group was additionally treated with atorvastatin 20 mg/d while high dose group was additionally treated with atorvastatin 40 mg/d, oral administration before going to bed. According to the above mentioned administration methods, the treatment lasted for a month. The differences in levels of TC, TG, HDL-C, LDL-C and IMT and plaque thickness were compared between the two groups before and after the experiment. Results Before the experiment, there was no significant difference in the indexes between the two groups(P 〉0.05); After the experiment,TC(2.64±0.75)mmol/L, TG(1.07±0.30)mmol/L, LDL-C(1.35±0.36)mmol/L, IMT(0.90±0.21)mm and plaque thickness(1.92±0.15) mm in high dose group decreased significantly, compared with those before experiment. After the experiment, TC(3.18±0.92)mmol/L, TG(1.41±0.34)mmol/L,LDL-C(2.71±0.41)mmol/L, IMT(1.09±0.34)mm and plaque thickness(2.37±0.23)mm in low dose group also decreased significantly, compared with those before experiment. After the experiment, there were significant differences between the two groups(P 〈0.05). Conclusion High dose atorvastatin in thetreatment of patients with carotid atherosclerosis is of good efficacy. It can significantly improve patient's blood lipids and reduce carotid intima media thickness.
出处
《中国处方药》
2016年第1期11-12,共2页
Journal of China Prescription Drug
关键词
阿托伐他汀
颈动脉粥样硬化
血脂
颈动脉内膜厚度
Atorvastatin
Carotid atherosclerosis
Blood lipid
Carotid intima media thickness