免疫抑制剂在炎症性肠病治疗中的应用

Application of immunosuppressants in the treatment of inflammatory bowel disease

炎症性肠病具有慢性发展、反复发作的特点,可导致肠道黏膜损伤、功能异常以及出血和穿孔等并发症,治疗目标是达到和维持疾病的"深度"缓解,从而改善疾病的长期自然病程。本文主要介绍目前在炎症性肠病治疗中免疫抑制剂的适当选用及其副作用,为临床合理、安全地选用免疫抑制剂治疗炎症性肠病提供参考。

Patients with inflammatory bowel disease（IBD） are characterized by the persistence and recurrence of the disease which can cause some complications such as intestinal mucosal damage,dysfunction and bleeding and perforation.The therapeutic goal is to achieve and maintain a ＂deep＂ remission of the disease and to improve the long-term nature course of disease outcomes.This paper focuses on an introduction of an appropriate choice of immunosuppressants and their adverse reactions in the treatment of IBD so as to provide references for a reasonable,safe choice of immunosuppressants in clinic.