产肠毒素性大肠杆菌菌毛的研究进展

Research Progress of Enterotoxigenic Escherichia Coli

产肠毒素性大肠杆菌(ETEC)常引起仔猪腹泻,在世界范围内造成了严重的经济损失。ETEC的致病作用与其具有粘附性菌毛和肠毒素密切相关,ETEC菌株的菌毛可与宿主黏膜上皮细胞表面的相应受体结合,并在局部组织定居、繁殖和产生毒素,损伤小肠黏膜,使小肠吸收分泌功能失常而致腹泻。本文针对ETEC菌毛的生物学特性、表达条件、免疫原性等方面作一概述。

Enterotoxigenic E. coli （ETEC） is a common factor that causing piglets diarrhea, ETEC strains settle in local tissue, multiply and produce toxins by combining with corresponding receptors on epithelial cell surface, then causeng intestinal mucosa damaging, the function of absorption and secretion unnormal, and leads to diarrhea. This paper summarized the biological characteristics, expressing condition and immunogenicity of ETEC＇s pili.