益心康泰胶囊联合硫氮唑酮治疗不稳定型心绞痛的疗效观察

Efficacy of Yixin Kangtai capsule combine with Diltiazem for unstable angina pectoris

目的研究益心康泰胶囊联合硫氮唑酮治疗不稳定型心绞痛患者的临床疗效。方法将98例不稳定型心绞痛患者分为对照组和联合治疗组,每组49例。对照组只给予常规抗心绞痛药物治疗,联合治疗组在其基础上另给予益心康泰胶囊与硫氮唑酮。均为30d一个疗程。结束后观察患者心绞痛症状、心电图ST-T、血液粘度值及血管内皮功能标志物-氧化氮(NO)和内皮素(ET)水平。结果治疗后联合治疗组患者临床总有效率高于对照组(P<0.05);联合治疗组患者心绞痛发作次数和持续时间低于对照组(P<0.05);联合治疗组患者心电图总有效率优于对照组(P<0.05);联合治疗组患者血液粘度值及ET水平较治疗前降低,而NO较治疗前增高(P<0.05)。结论益心康泰胶囊联合硫氮唑酮治疗不稳定型心绞痛患者疗效显著,且对不稳定型心绞痛患者的内皮功能具有保护作用。

Objective To study the clinical efficacy of unstable angina patients with the treatment of Yixin Kangtai capsule combine with diltiazem. Methods A total of 98 patients with unstable angina were randomly divided into control group and treatment group,49 in each group. The control group was given conventional anti-anginal drug therapy; while combination group was given Yixin Kangtai capsule combine with diltiazem on the basis of conventional anti-anginal medication. The course was 30 days; After the treatment,the symptoms of angina, ECG ST-T, blood viscosity and markers of endothelial function NO and ET levels were observed. Results After treatment,the total effective rate of the combination therapy group was higher than that of the control group （P〈0.05） l the angina attacks and its duration in combination therapy group were lower than that of control group（P〈 0.05） ;the total efficiency of electrocardiogram in combination therapy group was better than that of the control group （P〈0.05） blood viscosity values and ET levels of combination therapy group were reduced compared with before treatment （P〈0. 05）, but NO levels were increased（P〈0.05）. Conclusion Yixin Kangtai capsule combine with diltiazem have significant efficacy for unstable angina pectoris,and have protective effect on endothelial function in patients with unstable angina.