摘要
目的评估Ph染色体和BCR—ABL阴性骨髓增殖性肿瘤(MPN)患者体质性症状负荷。方法用骨髓增殖性肿瘤总症状评估量表(MPN—SAF.TSS)对628例MPN患者进行现场调查。结果疲劳在真性红细胞增多症(PV)、原发性血小板增多症(ET)和原发性骨髓纤维化(PMF)患者中的症状负荷和发生率均最高[分别为(3.46±2.97)、(3.47±2.99)、(4.74±3.04)分和76.O%、76.2%、89.9%]。患者的总症状负荷由高到低依次为PMF、PV、ET[分别为(28.9±19.1)、(19.2±16.8)、(17.1±15.3)分],PMF与Pv、ET比较差异均有统计学意义(x2=6.371,P=-0.021;x2=14.020,P〈0.001),PV与ET之间差异无统计学意义(x2=2.281,P=0.191)。结论MPN-SAF-TSS评估量表可有效评估MPN患者体质性症状,PV、ET和PMF患者中PMF的总症状负荷最高,用MPN—SAF—TSS评估量表进行症状评估应列为MPN治疗研究的评价指标。
Objective To investigate the value of myeloproliferative neoplasms Symptom Assessment Form total symptom score (MPN-SAF-TSS) in assessing constitutional symptoms among Ph/ BCR-ABL negative myeloproliferative neoplasm (MPN) patients. Methods A cohort of 628 MPN patients were evaluated by MPN-SAF-TSS. Results Fatigue was the most common symptom (76.0%, 76.2% vs 89.9%) and the highest average severity of all the symptoms (3.46±2.97, 3.47±2.99 vs 4.74±3.04 scores) among polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) patients. Using the MPN-SAF-TSS analysis, PMF patients showed highest burden of symptoms (28.9 ± 19.1), followed by PV patients (19.2 ± 16.8), and finally ET patients (17.1 ± 15.3). Instinct differences were observed between PMF and PV patients (x2=6.371,p=0.021 ), PMF and ET patients (Z2= 14.020, P〈0.001 ). No significant difference was found between PV and ET patients (Z2=2.281, P=-0.191 ). Conclusion MPN-SAF-TSS was effective in evaluating the symptomatic burden among Ph/BCRABL negative MPN patients and could be used for serial assessment in this clinical setting.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2016年第1期26-29,共4页
Chinese Journal of Hematology
基金
国家自然科学基金(81270585、81470297、81370611、81530008)
关键词
骨髓增殖性肿瘤
骨髓增殖性肿瘤总症状评估量表
症状
Myeloproliferative neoplasms
Myeloproliferative neoplasms symptom assessmentForm total symptom score
Symptom