药物联合植物性护肤品治疗多形性日光疹48例疗效观察

Clinical Observation of Combined Therapy of Drugs and Plant Cosmetic Products for the Treatment of 48 Patients Suffering from Polymorphous Light Eruption

目的探讨药物联合植物性护肤品治疗多形性日光疹的疗效及安全性。方法多形性日光疹患者96例,随机分为实验组(48例)和对照组(48例),所有患者均给予相同口服药(羟氯喹400 mg/d,分2次服用,氯雷他定5 mg/d,口服4周)及外用药物(糠酸莫米松乳膏外搽患处,使用2周后,改为外搽氟芬那酸丁酯软膏2周,均每天涂搽2次)。实验组患者在药物治疗的同时均使用植物性护肤品,对照组仅给予药物治疗。于治疗2周后、4周后评价2组疗效。治疗后对所有患者进行随访4周观察其复发率。根据患者临床症状和体征(包括皮损面积大小、红斑丘疹、浸润程度、瘙痒程度)进行疗效评判。结果治疗4周后,实验组有效率为47.92%,对照组有效率为33.33%,两组疗效比较差异有统计学意义(P<0.05)。随访后发现实验组复发率(37.50%)明显较对照组(75.00%)低,差异有统计学意义(P<0.05)。所有患者用药和护肤品期间均未出现严重的不良反应。结论药物联合植物性护肤品治疗多形性日光疹疗效较好,安全性高。

Objective To evaluate the efficacy and safety of drugs combined with plant cosmetic products in the treatment of polymorphous light eruption. Methods Ninety six patients diagnosed as polymorphous light eruption were recruited and randomized into experimental group （48 cases） and control group （48 cases）. The Patients in both groups received same oral drugs（ hydroxychloroquine, 100mg per tablet, 4 tablets per day, taken at twice and loratadine ,Stag per tablet, 1 tablet daily for 4 weeks）, simutaneously using external use in the experimental group （ topically applied 0. 1% mometasone furoate cream twice a day for 2 weeks firstly, and then changed to topically apply buty flufenamate ointment twice a day for another 2 weeks）. Plant cosmetic products were used externally in experimental group in treatment period. The efficacy rate was evaluated in both of groups after two weeks and four weeks. The curative effect evaluation was conducted according to clinical signs and symptoms, including skin lesion area size, erythema papula, infiltration degree, and itching degree. Results Four weeks after treatment, the effective rate of the experimental group was 47.92%, while the control group effective rate was 33.33%, indicating a significant difference （ P 〈 0. 05）. The recurrence rate of experimental group （37.50%） was obviously lower than the control group （ 75.00% ） during follow-up （ P 〈 0. 05 ）. All the patients had no severe adverse reactions during the treatment. Conclusion The curative effect of drugs combined with plant cosmetic products therapy for polymorphous light eruption was better and the treatment has better safety.