Th17细胞在慢性鼻-鼻窦炎中的研究进展

Progress of Th17 cells in chronic rhinosinusitis

慢性鼻-鼻窦炎（chronic rhinosinusitis,CRS）是耳鼻咽喉科的常见病和多发病,是鼻黏膜的一种非特异性慢性炎症反应,目前其治疗效果尚不够理想,且复发率居高,但其确切的发病机制仍旧不清楚。T淋巴细胞在人体免疫系统中起核心作用,其活化后通过分泌细胞因子等对其他免疫细胞的活化、增殖和效应方面发挥重要作用。

Chronic rhinosinusitis is a common disease and frequently encountered disease in otolaryngology,but the therapeutic effect is not ideal.While its pathogenesis is exploring in the continuously.Found in the recent years,Th17 cells are a new subset of T cells and closely related with inflammatory disorders,autoimmune diseases and cancer.Its differentiation,regulation and biological effects are widely noted as a hot area of research.This review explores the discovery of differentiation and regulation of Th17 cells,the relationship between related cytokines and chronic rhinosinusitis,in order to have a beteer knowledge of chronic rhinosinusitis.This review regards Th17 cells as the main clue,nevertheless,lacking consideration of the impacts of other factors on chronic rhinosinusitis.