CXCL9在新疆寻常型银屑病患者中的表达

Expression of CXCL9 in Patients with Psoriasis Vulgaris in Xinjiang

目的比较新疆地区寻常型银屑病患者皮损及正常人群皮肤中干扰素伽玛诱导的单核细胞因子(CXCL9)的表达差异。方法 Envision免疫组织化学法(IHC)检测新疆寻常型银屑病患者皮损及正常人皮肤中CXCL9的表达情况。结果与正常皮肤组织相比,CXCL9在寻常型银屑病皮损中的表达明显增加,主要以真皮乳头顶端为主,且差异具有明显统计学意义(χ2=34.80,P<0.01);新疆地区汉族寻常型银屑病患者和维吾尔族寻常型银屑病患者皮肤组织中CXCL9的表达差异无统计学意义(χ2=1.64,P>0.05)。结论新疆寻常型银屑病患者皮损中CXCL9的表达升高,通过JAK/STAT信号通路在寻常型银屑病的炎症反应中发挥重要作用;但汉族和维吾尔族寻常型银屑病患者皮损中CXCL9的表达相似。

Objective The expression differences of CXCL9 between lesions and normal skin tissues of patients with psoriasis vulgaris in xinjiang are compared. Methods Envision immunohistochemical method was used to detect the expression of CXCL9 in lesions of patrents with psoriasis vulgaris and in normal skin tissue in Xinjiang respectively. Results Compared with normal skin, the expression of CXCL9 in Xinjiang psoriasis vulgaris patients lesions was obviously increased, expressing in the top of the dermal papilla and the basal layer mainly, and differences were statistically significant（χ2=34.80,P〈0.01）. However,the differences of CXCL9 expression between Han and Uyghur psoriasis vulgaris patinets had no statistically significance（χ2=1.641,P〉0.05）. Conclusion The expression of CXCL9 in the lesions of patients with psoriasis vulgaris are upregulated,and it contribute to the inflammatory response and hyperplasia of keratinocytes in vulgaris paoriasis via JAK/STAT signaling pathway. But there is no difference of expression of CXCL9 between Han and Uyghur psoriasis vulgaris.