疏肝活血方治疗更年期女性皮肤瘙痒症疗效观察

Clinical Efficacy of Shugan Huoxue Formula in Treating Menopausal Women with Skin Pruritus

目的观察疏肝活血方治疗更年期女性皮肤瘙痒症的疗效及作用机制。方法 60例患者随机分为对照组和治疗组,每组30例,治疗组服用疏肝活血颗粒,2次/d;对照组服用盐酸左西替利嗪,1次/d。治疗4周后,观察患者瘙痒症状评分、皮损评分、组胺(Histamine,HIS)、β-内啡肽(β-endorphin,β-EP)的变化。结果治疗组总有效率为93.3%,对照组为70%,2组更年期女性皮肤瘙痒症患者瘙痒症状评分和皮损评分显著下降,HIS、β-EP水平均明显下降,差异有统计学意义(P<0.01)。结论疏肝活血方治疗更年期女性皮肤瘙痒症疗效显著,其降低HIS、β-EP的作用可能是治疗更年期女性皮肤瘙痒症的机制之一。

Objective To observe the clinical efficacy and mechanism of Shugan Huoxue formula in treating menopausal women skin pruritus. Methods All of 60 patients were divided into control group and treatment group, 30 cases in each group,the treatment group was taken Shugan Huoxue particles, twice a day. The control group was taken Cetirizine Hydrochloride everyday. After four weeks, the changes of Urticant symptom score, lesion score, histamine（HIS） and β-endorphin（β-EP） was observed. Results The total effective rates in treatment group and in control group were 93.3% and 70%, pruritus urticant symptom scores and lesion scores of menopausal women patients of two groups were decreased significantly. HIS and β-EP levels were significantly decreased. It had significant differences after treatment（P〈0.01）. Conclusion Clinical efficacy of Shugan Huoxue formula in treating menopausal women with sin puritus were significant. The decrcase of the levels of HIS andβ-EP may be one of the mechanisms in treating menopausal women with skin pruritus.