祛斑汤治疗气滞血瘀型黄褐斑疗效及对外周血中血管内皮生长因子的影响

Clinical Efficacy and Influence on the Level of Vascular Endothelial Growth Factor in Peripheral Blood of Quban Decoction in Treating Chloasma with Syndrome of Qi-stagnation and Blood Stasis

目的探讨祛斑汤治疗气滞血瘀型黄褐斑临床疗效及对黄褐斑患者外周血中血管内皮生长因子(VEGF)水平的影响。方法将90例辨证为气滞血瘀型的黄褐斑患者按随机数字表法分为治疗组(54例)和对照组(36例),分别予以祛斑汤和维生素C、E药物治疗。并设正常健康组(30例)。12周后分别测定治疗前后外周血血清中VEGF水平,并比较2组临床疗效。结果气滞血瘀型黄褐斑患者治疗前血清VEGF水平明显低于对照组,经治疗后治疗组血清VEGF水平升高,差异有统计学意义(P<0.05),且与健康组比较差异无统计学意义(P>0.05),而对照组患者经治疗前后血清VEFG水平比较差异无统计学意义(P>0.05),治疗后,治疗组和对照组VEFG水平比较差异有统计学意义(P<0.05)。临床治疗组总有效率高于对照组(P>0.05)。结论祛斑汤可上调血清VEGF水平,通过改善血循环、活血化瘀达到治疗黄褐斑的功效,且临床疗效优于对照组,值得临床推广应用。

Objective To explore the clinical efficacy and influence on the level of vascular endothelial growth factor（VEGF） in peripheral blood of Quban decoction in treating chloasma with syndrome of Qi-stagnation and blood stasis. Methods All of 90 patients were randomly divided into two groups including the Quban decoction group（54 cases） and the Vitamin C and Vitamin E group（36 cases）. The levels of VEGF in peripheral blood were evaluated before and after the treatment for 12 weeks compared with normal control group（30 cases）. The clinical efficacies were also evaluated in both groups. Results The level of VEGF in chloasma patients was obviously lower than normal control group before treatment. After treatment, the level of VEGF in Quban decoction group increased obviously（P〈0.05） and there was obvious differences between control group and treatment group in the level of VEGF（P〈0.05）. The total effective rate of treatment groups was higher than contrd group（P〈0.05）. Conclusion Qub an decoction can increase the level of VEGF in peripheral blood and improve the blood circulation to remove blood stasis of chloasma. The clinical efficacy of treatment group is better than control group. It is worth to be applied in clinic.