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IL-37对炎症相关性疾病的抑制作用 被引量：8

Inhibitory effect of IL-37 on inflammation-related diseases
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摘要 IL-37属IL-1家族细胞因子,最初发现时被命名为IL-1F7,具有5种不同的亚型(IL37a^e)。研究已证实,IL-37能够抑制多种免疫细胞中促炎性细胞因子的产生,进而调节固有免疫应答;此外,IL-37对外源性刺激诱导的结肠炎、关节炎、胰腺炎等炎症性疾病具有一定的保护作用。总之,IL-37能够在多种炎症相关性疾病中发挥抑制作用,是一种新型的炎症抑制因子。 Inteleukin-37 is a member of IL-1 family and originally named as IL-1F7. It has five different subtypes（ IL-37a-e）. It has been reported that IL-37 suppresses pro-inflammatory cytokines production of a variety of immune cells,and further regulate innate immune response. In addition, IL-37 has protective effects on colitis, arthritis,pancreatitis and other inflammatory diseases that induced by exogenous stimuli. In a word, IL-37 is a novel antiinflammatory cytokine and plays an important role in a variety of inflammation-related diseases.
作者 李梦媛 杨星九 徐大模 高苒
机构地区 中国医学科学院医学实验动物研究所
出处 《中国比较医学杂志》 CAS 北大核心 2015年第12期75-80,共6页 Chinese Journal of Comparative Medicine
基金 协和青年基金资助 中央高校基本科研业务费专项资金资助(33320140192) 中国医学科学院医学实验动物研究所基本科研业务费专项资助(DWS201301)
关键词 IL-37 炎症抑制因子 炎性疾病 IL-37 Anti-inflammatory cytokine Inflammation-related diseases
分类号 R-33 [医药卫生]
  • 相关文献

参考文献30

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二级参考文献60

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  • 7Gao W, Kumar S, Lotze MT, Hanning C, Robbins PD, Gambotto A. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol 2003; 170(1): 107-13.
  • 8Kumar S,Hanning CR, Brigham-Burke MR,Rieman DJ, Lehr R, Khandekar S, et al. Interleukin-1 F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine 2002; 18(2):61-71.
  • 9Song L, Qiu F, Fan Y, Ding F, Liu H, Shu Q, et al. Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus. J Clin Immunol 2013; 33(1): 111-7.
  • 10Bufler P, Azam T,Gamboni-Robertson F,Reznikov LL, Kumar S, Dinarello CA, et al. A complex of the IL-1 homologue IL-lF7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci USA 2002; 99(21): 13723-8.

共引文献111

同被引文献93

引证文献8

二级引证文献65

中国比较医学杂志
2015年 第12期

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