慢性阻塞性肺疾病急性加重期合并贫血的易患因素分析

Analysis of the susceptible factors of acute exacerbation period of chronic obstructive pulmonary diseases combined with anemia

目的了解慢性阻塞性肺疾病急性加重期(Acute Exacerbation Chronic Obstructive Pulmonary Disease,AECOPD)合并贫血的发生率、贫血类型及严重度,分析AECOPD合并贫血的易患因素。方法对纳入研究的113例患者分为贫血组28例和非贫血组85例(含2例高血红蛋白)。检测记录两组患者的性别、年龄、身高、体重、BMI、病程、急性加重时间、ALB及超敏CRP。结果 113例AECOPD患者中贫血28例(24.78%),贫血类型以正常细胞性贫血为主。两组患者的性别、病程及急性加重时间差异无统计学意义(P>0.05);贫血组患者年龄、超敏CRP高于非贫血组患者,而贫血组的BMI及ALB水平则低于非贫血组患者(P<0.05);Hb与年龄无关,与BMI、ALB均呈正相关(P<0.05),与超敏CRP呈负相关(P<0.05)。结论 AECOPD合并贫血的患病率为24.78%,以正常细胞性轻度贫血为主;COPD患者贫血合并症的发生与年龄、营养状况及炎症反应水平有相关性。

Objective To understand the incidence of anemia, anemia type and severity of acute exacerbations of chronic obstructive pulmonary disease and analyze the risk factors. Methods Patients were divided into anemia and non anemia groups, according to the diagnostic standard of anemia. Two groups of patients were recorded gender, age, height, weight, body mass index （BMI）, course of disease, acute exacerbation time, ALB and high-sensitivity C-reactive protein. Results Among the 113 AECOPD patients, 28 cases （24.78%） were anemia. The type of anemia was mainly normal cell anemia. The sex, course of disease and acute exacerbation of the time of the two groups had no difference （P〉0.05）. In anemia group, the age and high sensitive CRP were higher than that of the non anemia group, but BMI and ALB levels were lower than the other grou （P〈0.05）. There was no linear correlation between Hb and age. There was a positive correlation between Hb and BMI, ALB（P〈0.05）. Hb was negatively correlated with high sensitive CRP （P〈0.05） in anemia group. Conclusion AECOPD associated anemia prevalence rate was 24.78% ,and the type of anemi- a is normal cell mild anemia. Anemia in patients with COPD has relationship with age, nutritional status and inflammatory response.