摘要
目的探讨嗜神经浸润(PNI)与宫颈癌临床、病理特征的关系及其意义。方法对206例宫颈癌患者的临床及病理资料进行回顾性分析,分析宫颈癌PNI与宫颈癌临床、病理特征的关系,以及PNI与宫颈癌术后辅助放疗的关系。结果 206例宫颈癌中PNI的发生率为16.0%(33/206)。单因素分析提示,PNI阳性与肿瘤临床分期、肿瘤分化程度、肿瘤大小、浸润深度、淋巴脉管间隙浸润(LVSI)、淋巴结转移有关(P<0.05)。多因素分析显示,LVSI及淋巴结转移与宫颈癌PNI阳性相关(P<0.05)。PNI阳性患者需要术后辅助放疗的比例高于PNI阴性患者(P<0.05)。结论宫颈癌PNI阳性与LVSI、淋巴转移关系密切,PNI阳性有助于评估术后是否需要辅助放疗。
Objective To explore the relationship between perineural invasion( PNI) and clinicopathologic characteristics of cervical cancer and its significance. Methods The clinical and pathologic data of 206 patients with cervical cancer were retrospectively analyzed. The relationship between PNI and clinicopathologic characteristics of cervical cancer was evaluated. The relationship between PNI and postoperative adjuvant radiotherapy for cervical cancer was also assessed. Results In 206 cases of cervical cancer,the incidence of PNI was 16. 0%( 33 /206).Univariate analysis showed that positive PNI correlated with clinical stage of tumor,degree of tumor differentiation,tumor size,depth of invasion,lymphovascular spare invasion( LVSI) and lymph node metastasis( P 〈 0. 05). Multivariate analysis showed that LVSI and lymph node metastasis correlated with positive PNI( P 〈0. 05). The proportion of patients with positive PNI who needed postoperative adjuvant radiotherapy was higher than that of patients with negative PIN( P 〈0. 05). Conclusion Positive PNI closely correlates with LVSI and lymph node metastasis in cervical cancer,and it can be helpful for evaluating whether postoperative adjuvant radiotherapy is necessary.
出处
《广西医学》
CAS
2015年第11期1562-1565,共4页
Guangxi Medical Journal
基金
广西医疗卫生适宜技术研究与开发课题(S201301-01)
关键词
宫颈癌
嗜神经浸润
危险因素
术后放疗
Cervical cancer
Perineural invasion
Risk factor
Postoperative radiotherapy