氯吡格雷联用阿司匹林治疗糖尿病并发急性脑梗死临床分析

Clinical analysis of clopidogrel combined with aspirin in treatment of diabetes patients complicated with acute cerebral infarction

目的探讨氯吡格雷与阿司匹林联用治疗糖尿病并发急性脑梗死的临床价值。方法选择2011年4月至2015年2月我院收治的糖尿病并发急性脑梗死患者150例作为研究对象,随机分为三组,每组50例。三组患者均给予常规治疗,在此基础上,对照一组患者给予阿司匹林治疗,对照二组患者给予氯吡格雷治疗,观察组患者联用阿司匹林、氯吡格雷治疗。观察分析三组患者的临床疗效以及NIHSS评分。结果观察组患者治疗总有效率(92.0%)显著高于对照一组(70.0%)和对照二组患者(72.0%),差异有统计学意义(P<0.05);观察组患者临床疗效显著优于对照一组和对照二组患者(P<0.01)。治疗后观察组患者NIHSS评分显著低于对照一组和对照二组患者,差异有统计学意义(P<0.01)。结论联用阿司匹林与氯吡格雷治疗糖尿病并发急性脑梗死患者,能发挥药物协同作用,增强疗效;同时能改善患者脑部血供,减轻神经功能缺损,促进神经功能恢复。

Objective To observe the clinical value of clopidogrel combined with aspirin in treatment of diabetes patients complicated with acute cerebral infarction. Methods A total of 150 cases of diabetes patients complicated with acute cerebral infarction were selected and randomly divided into three groups, with 50 cases in each group. All patients received regular treatment, meanwhile, the first control group was given aspirin, the second control group was given clopidogrel, while the observation group was treated with clopidogrel combined with aspirin. The clinical effect and NIHSS score among the three groups were compared. Results The total efficiency of the observation group was 92%, which was significantly higher than that of the first control group and the second control group （70.0%, 72.0%, respectively, P 〈 0.05 ）; and the efficacy of the observation group was significantly superior to the first and the second control group （P 〈 0.01 ） ; the NIHSS score in the observation group was significantly lower than that of other two groups（P 〈 0.05）. Conclusions Clopidogrel combined with aspirin has a synergistic effect on diabetes patients complicated with acute cerebral infarction, it can increase curative effect and improved the providing of blood to the brain, alleviate neurologic impairment, improve neural function.