Nrf2对肿瘤作用的两面性

Dual roles of Nrf2 in tumorigenesis

核转录因子红细胞系-2p45（NF-E2）相关因子-2（nuclear factor erythroid-2p45-related factor2，Nrf2）介导的细胞适应性氧化应激反应是人体重要的抗氧化防御系统，对于抗致癌物的氧化损伤起重要作用。然而，该信号通路的持续激活又促进了肿瘤发生及耐药性的增加。Nrf2在肿瘤发生过程中发挥的这种“相互矛盾”的作用在肿瘤防治领域也越来越受关注。文章综述了Nrf2在肿瘤形成过程中的正反两方面作用及其在肿瘤防治中的应用。

Activation of the transcription factor NF-E2-related factor 2 （Nrf2）-signaling pathway is an adaptive response to environmental and endogenous stresses and serves to render animals resistant to chemical carcinogenesis and other forms of toxicity. However, overexpression of Nrf2 has been recognized to promote oncogenesis and resistance to chemotherapy. The application of Nrf2 in tumor chemoprevention and treatment has also become a hot topic. This review focuses on the dual roles of Nrf2 in tumorigenesis and the application of Nrf2 in tumor chemoprevention and treatment.