中重度OSAHS患者血糖血脂水平临床分析

CLINICAL ANALYSIS OF BLOOD GLUCOSE AND BLOOD LIPID LEVEL OF PATIENTS WITH MODERATE-SEVERE OBSTRUCTIVE SLEEP APNEA-HYPOPNEA SYNDROME

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者血清血糖和血脂水平的变化。方法:入选中度OSAHS患者、重度OSAHS患者和健康者各35例。所有研究对象均行多导睡眠监测(PSG)并检测受试者血清空腹血糖(FPG)、甘油三酯(TG)、胆固醇(Chol)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)的水平。结果:中、重度OSAHS组呼吸暂停低通气指数(AHI)、FBP、TG、Chol和LDL明显高于健康对照组,LaSO_2、HDL明显低于健康对照组(P<0.01);重度OSAHS组AHI、FBP、TG、Chol和LDL明显高于中度组,LaSO_2、HDL明显低于中度组(P<0.01)。结论:OSAHS患者空腹血糖、血脂水平均明显升高,且与睡眠呼吸暂停严重程度有关,监控OSAHS患者血糖、血脂水平对OSAHS患者的预后和转归具有重要作用。

Objective：To investigate the changes of blood glucose and blood lipid level in serum of obstructive sleep apnea-hypopnea syndrome（OSAHS） patients.Methods：Healthy control group,moderate OSAHS group and severe OSAHS group respectively had 35 cases.All the participants were monitored by polysomnography（PSG）;and the fasting plasma glucose（FPG）,triglyceride（TG）,cholesterol（Chol）,low-density lipoprotein（LDL） and high-density lipoprotein（HDL）level in serum of all the participants were detected.Results：The AHL FBP,TG,Chol and LDL of patients in moderate OSAHS group and severe OSAHS group were obviously higher than healthy control group（P〈0.01）;While the LaSO_2 and HDL were obvious lower（P〈0.01）.The AHI,FBP,TG,Chol and LDL of patients in severe OSAHS group were obviously higher than moderate OSAHS group（P〈0.01）;But the LaSO_2 and HDL were obvious lower（P〈0.01）.Conclusions：The blood glucose and blood lipid level of OSAHS patients increase obviously,and related to the severity of OSAHS.Monitoring the blood glucose and blood lipid level play an important role in prognosis and outcome of OSAHS.