摘要
泌乳素瘤是最常见的具有内分泌功能的垂体瘤。对于泌乳素瘤的发病机制,目前认为可能与原癌基因和抑癌基因的改变及生长因子的变化有关。骨形态发生蛋白4(BMP-4)、视黄酸、过氧化物酶增殖物激活受体γ(PPAR-γ)、CCAAT增强子结合蛋白δ和神经调节蛋白1可能也参与了泌乳素瘤的发病。此外,肿瘤微环境在垂体肿瘤的发生中所起的作用也逐渐受到关注。但各种发病机制间的相互联系仍未明确,因此,泌乳素瘤发病机制的研究还应深入。
Prolactinoma is the most common type of secretory pituitary tumors. The pathogenesis of prolactinomas might be associated with the change of protooncogene,antioncogene,and growth factors. Recent studies have shown that bone morphogenetic protein 4（ BMP-4）,retinoic acid,peroxisome proliferator-activated receptor γ（ PPAR-γ）,neuregulin-1 and CCAAT enhancer binding protein δ（ CEBPD） may also be involved in the pathogenesis of prolactinomas. Besides,microenvironment may play potential roles in the development of prolactinomas. However,the linkages among the various regulation pathways are not yet clear,further investigation of prolactinoma pathogenesis is urgently needed.
出处
《医学综述》
2016年第1期55-59,共5页
Medical Recapitulate
基金
国家自然科学基金(30900805
81370884)
