1型糖尿病动脉粥样硬化与脂联素、转化生长因子β_1及Ⅳ型胶原蛋白的关系

The Relationship of Type 1 Diabetes Mellitus Atherosclerosis with APN and TGF-β_1 and Type ⅣCollagen

1型糖尿病动脉粥样硬化的发病率及患病率逐年上升,已严重影响患者生活质量。由于其发展迅速、病情严重且发病机制尚未明确,越来越受到人们的关注。脂联素、转化生长因子β1、Ⅳ型胶原蛋白参与了1型糖尿病动脉粥样硬化形成、发展中的多个关键性的病理过程。该文通过探讨脂联素、转化生长因子β1、Ⅳ型胶原蛋白三者的关系及其对1型糖尿病动脉粥样硬化的影响,为1型糖尿病大血管并发症的预防、诊断、治疗指明新的研究方向。

Type 1 diabetes atherosclerosis incidence and prevalence has been rising year by year,which has seriously affected the patients＇ quality of life. Due to the rapid development,serious disease condition,and the pathogenesis is not yet clear,more and more attention has been drawn. Adiponectin,transforming growth factor β1,type IV collagen are involved in the formation and multiple critical pathological processes of type 1 diabetes atherosclerosis. Here,by discussing adiponectin,transforming growth factor β1,type IV collagen and the relationships between the three,the effects on type 1 diabetes atherosclerosis,we intend to find out new research directions for the prevention,diagnosis,treatment of type 1 diabetes macrovascular complication.