阴茎包皮原发性恶性黑色素瘤的诊断与治疗

Diagnosis and treatment of primary malignant melanoma of the foreskin

目的探讨阴茎原发恶性黑色素瘤的生物学行为、临床病理特点、诊断治疗方法及其预后。方法报告1例阴茎包皮原发恶性黑色素瘤的诊断治疗及随访情况,并结合国内外文献进行分析。结果本例患者肿瘤分期为Ⅰ期,行阴茎部分切除术及双侧腹股沟淋巴结清扫术,同时给予化疗及免疫治疗,术后随访54个月无复发转移。结论阴茎原发恶性黑色素瘤临床罕见,恶性程度高;其确诊依靠病理;外科手术为主要治疗手段,术后结合化疗以及免疫治疗可延长生存期,但总体预后差。

Objective To discuss the biological and pathological features,diagnosis,treatment and prognosis of primary malignant melanoma of the foreskin. Methods The diagnosis,treatment,and follow-up of one case of primary malignant melanoma of foreskin treated in our hospital was reported,and the related literatures were reviewed. Results The tumour stage of the patient was stage I,and the patient was given partial amputation of the penis and bilateral inguinal lymph node dissection. Chemotherapy and immunotherapy were conducted at the same time. And there was no recurrence metastasis of during the postoperative follow-up of 54 months. Conclusion Primary malignant melanoma of the foreskin is rare in clinical and it is of high malignant degree. Its diagnosis depends on pathology and surgery is the main treatment. Postoperative chemotherapy and immunotherapy can prolong the survival time of patients,but the overall prognosis is poor.