中药有效成分治疗慢性前列腺炎的免疫机制

Immune mechanisms of the active ingredients of Chinese medicinal herbs for chronic prostatitis

慢性前列腺炎是男性多发病和常见病,然而慢性前列腺炎的病因机制还未明确,目前大多数学者认为氧化应激和免疫调节失衡是慢性前列腺炎发生的关键机制。目前免疫疗法在慢性前列腺炎治疗中仍然属于探索阶段,本文就5种中草药有效成分在慢性前列腺炎的实验和临床研究中其可能机制进行阐述,主要体现在:1抑制免疫反应,抑制T细胞活性与增殖,调节Th1/Th2细胞的比例。2上调Treg细胞的表达,从而增强患者耐受能力。3抑制NK-κB因子并进一步抑制i NOS,减少NO、IL-2等炎症因子的释放,起到抑制免疫反应作用。4抑制趋化因子的产生如MCP-1、MIP-1α,以此来减轻诱导炎症反应。研究中草药治疗慢性前列腺炎的免疫机制对开发新药、发扬传统医学有一定的临床价值。

Chronic prostatitis is a common male disease,and its pathogenesis is not yet clear. Most scholars believe that oxidative stress and immune imbalance are the keys to the occurrence and progression of chronic prostatitis. Currently immunotherapy of chronic prostatitis remains in the exploratory stage. This article relates the active ingredients of 5 Chinese medicinal herbs（ total glucosides of paeony,tripterigium wilfordii polglycosidium,curcumin,geniposide,and quercetin） for the treatment of chronic prostatitis and their possible action mechanisms as follows： 1） inhibiting the immune response and activation and proliferation of T-cells,and adjusting the proportion of Th1 / Th2 cells; 2） upregulating the expression of Treg and enhancing the patient＇s tolerability; 3） suppressing the activation of the NF-k B factor,reducing the release of i NOS,and further decreasing the release of NO,IL-2 and other inflammatory cytokines,which contribute to the suppression of the immune response; 4） inhibiting the production of such chemokines as MCP-1 and MIP-1α in order to reduce their induction of inflammatory response. Studies on the immune mechanisms of Chinese medicinal herbs in the treatment of chronic prostatitis are clinically valuable for the development of new drugs for this disease.