红斑狼疮患者1006例临床特征研究：来自中国人群红斑狼疮多中心病例对照研究（LEMCSC）

Clinical characteristics of 1 006 Chinese patients with lupus erythematosus： results from the Lupus Erythematosus Multicenter Case-control Study in Chinese populations （LEMCSC）

目的 探讨中国红斑狼疮（LE）患者的临床特征。 方法 从中国人群LE多中心病例对照研究（LEMCSC）中获得数据，以统一标准纳入样本及收集临床资料。用EpiData 3.1录入数据和SPSS 18.0 统计数据。 结果 共有1 006例LE患者（女性87.6%）纳入分析，其中系统性红斑狼疮（SLE）887例（女性89.9%），无内脏系统受累的皮肤型红斑狼疮（CLE）119例（女性70.6%）。SLE患者各系统受累情况是皮肤（72.7%） 〉 关节（69.2%） 〉 血液（60.8%） 〉 肾脏（48.5%） 〉 浆膜（18.2%） 〉 神经系统（5.7%）。LE特异性皮损的出现可增加伴发关节炎风险［OR = 1.612，95%可信区间（CI）1.181 - 2.200］，却可降低伴发肾炎和浆膜炎的风险（OR分别为0.218及0.311；95% CI分别为0.157 - 0.303及0.218 - 0.443）。急性皮肤型红斑狼疮皮损的出现是伴发系统受累的危险因素（OR = 4.931，95% CI 3.232 - 7.524），而慢性皮肤型红斑狼疮皮损的出现却是伴发系统受累的保护因素（OR = 0.355，95% CI 0.234 - 0.541）。LE非特异性皮损的出现与内脏受累密切相关。 结论 揭示中国LE患者的基本临床特征以及LE相关皮损与内脏器官受累的关系。

Objective To explore clinical characteristics of Chinese patients with lupus erythematosus （LE）. Methods Data were obtained from the Lupus Erythematosus Multicenter Case-control Study in Chinese populations （LEMCSC）. A unified standard was used to recruit patients and collect clinical information. The EpiData 3.1 and SPSS 18 softwares were utilized to input and analyze data respectively. Results One thousand and six patients （87.6% female） with lupus erythematosus （LE） were included in this analysis, of whom, 887 （89.9% female） had systemic LE （SLE）, and 119 （70.6% female） had isolated cutaneous LE （CLE）. The most common involved system in SLE patients was skin （72.7%）, followed by joints （69.2%）, hematological system （60.8%）, kidney （48.5%）, serosa （18.2%）, and nervous system （5.7%）. The appearance of LE-specific skin manifestations was associated with an increased risk of arthritis （odds ratio [OR] =1.612,95% confidence interval [CI]： 1.181 - 2.200）, but with a decreased risk of nephritis （OR = 0.218, 95% CI： 0.157 - 0.303） and serositis （OR = 0.311, 95% CI： 0.218 - 0.443）. The presence of acute CLE （ACLE） lesions was a risk factor for systemic involvement （OR = 4.931, 95% CI： 3.232 - 7.524）, while that of chronic CLE （CCLE） lesions was a protective factor for systemic involvement （OR = 0.355, 95% CI： 0.234 - 0.541）. The appearance of LE-nonspecific skin manifestations was closely correlated with the involvement of internal organs in patients with LE. Conclusion This study revealed main characteristics of LE patients in China and the relationship between LE-related skin lesions and internal organ involvement.