摘要
目的评估长期口服桉柠蒎治疗稳定期慢性阻塞性肺疾病(COPD)的疗效。方法共纳人稳定期COPD患者120例,随机分为桉柠蒎组63例和对照组57例,桉柠蒎组采用常规治疗联合桉柠蒎治疗,对照组则仅采用常规治疗,主要临床终点为年急性加重次数,次要临床终点为肺功能指标及圣乔治呼吸问卷(SGRQ)评分。结果经1年治疗后急性加重发生次数分别为桉柠蒎组0.70次/年、对照组为1.21次/年,桉柠蒎组明显低于对照组(Z=-3.887,P=0.000);1年内桉柠蒎组与对照组患者未发生急性加重的比例分别为25.4%(16/63)和5.3%(3/57)(x^2=9.103,P=0.003)。两组用力肺活量(FVC)、第1秒用力呼气容积(FEV,)、第1秒用力呼气容积占预计值百分比(FEVl00)5次不同时间测量差异有统计学意义(桉柠蒎组:F=15.429、36.389、33.278,均P=0.000;对照组:F=54.238、94.213、83.774,均P=0.000),桉柠蒎组FEV1/FVC5次不同时间测量差异无统计学意义(F=0.861,P=0.451),对照组FEV1/FVC5次不同时间测量差异有统计学意义(F=2.766,P=0.043);两组患者治疗后SGRQ评分中各项评分均较治疗前有所下降,且治疗后两组患者症状评分差异有统计学意义(t=2.109,P=0.037)。桉柠蒎组共有3例(4.8%)出现不良反应,对照组有2例(3.5%),桉柠蒎组与对照组不良反应发生率差异无统计学意义(x^2=0.013,P:0.732)。结论长期口服桉柠蒎可以减少稳定期COPD患者急性加重的次数、改善生活质量、延缓肺功能下降趋势,且安全性较好。
Objective To evaluate the efficacy of eucalyptol-limonene-pinene enteric capsule on stable chronic obstructive pulmonary disease (COPD) in the elderly. Methods A total of 120 patients with stable COPD were randomized into ELP group (n = 63) with conventional treatment combined ELP and control group (n= 57) with conventional treatment without ELP. Primary outcome was the number of exacerbations per year, and secondly outcomes were lung function parameters and St. George's Respiratory Questionnaire (SGRQ). Results After 1 year of treatment, numbers of exacerbations per patient per year were lower in ELP group than in control group (0.70 times/y vs. 1.21 times/y, Z=- 3. 887, P=0. 000). The proportion of exacerbation-free patients were 25.4% (16/63) in ELP group and 5.3% (3/57) in control group (x^2 =9. 103, P=0. 003). The differences in the forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and FEV1/ FVC ratio (FEV1%) between 5 different time points measurements were statistically significant in both groups (ELP group:F=15.429, 36. 389, 33. 278, respectively, all P=0.000;control group:F= 54. 238, 94. 213 and 83. 774, respectively, all P=0. 000). Difference in FEV1/FVC ratio between 5 different time point was statistically significant in control group(F=2.766,P=0.043), but not in ELPgroup(F=0.861,P=0.451). After treatment, SGRQ score was decreased in both group, and difference in symptom score was statistically significant between the two groups ( t = 2. 109, P= 0. 037). The adverse reactions were found in 3 cases in ELP group, and in 2 cases in control group with no statistically significant difference between the two groups (3 (4.8%) vs. 2 (3.5%), x^2 = 0. 013, P= 0. 7321. Conclusions Long-term oral administration of eucalyptol-limonene-pinene enteric capsule can significantly decrease exacerbation frequency, improve quality of life, delay the deterioration in lung function, and have good safety in elderly patients with stable COPD.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2016年第1期33-37,共5页
Chinese Journal of Geriatrics
基金
中华医学国际交流基金会专项基金项目(CIMF-2013-XM-25)
关键词
肺疾病
慢性阻塞性
呼吸功能试验
Pulmonary disease, chronic obstructive
Respiratory function tests Fund program : China International Medical Foundation(CIMF 2013-XM-25 )