基于细胞间的有向加权通信网络定量评价蛹虫草对人体的调节作用

Quantitative Evaluation of the Regulatory Effect of Cordyceps militaris on Human Body with the Intercellular Directed Weighted Communication Networks

基于有向加权图构建食用低、中、高剂量蛹虫草诱导机体所产生的3个细胞间无线通信网络模型,并借助各种统计量对其进行定量化系统分析,验证这些参数是否能够从不同的角度定量刻画网络的状态、性质、结构和功能。结果表明:服用不同剂量的蛹虫草诱导机体产生的无线通信网络具有层次结构,并表现出一定的稳健性。同时,不同蛹虫草服用剂量能够改变细胞在通信中的重要性和扮演的角色。蛹虫草主要发挥下调机体细胞间无线通信网络的功能,说明它对于过敏反应、过度营养所造成的现代代谢综合征、心脑血管疾病等可能具有很好的保健和抗炎症功能。中剂量蛹虫草的平均作用强度最大,当进一步增加蛹虫草剂量时作用强度反而下降,这表明不同剂量的蛹虫草对于机体的免疫和生理内分泌具有非线性和双向调节功能。

Based on the directed weighted graph, three intercellular wireless communication networks are constructed, which are generated in young and healthy volunteers consuming Cordyceps militaris at low, medium and high doses. The quantitative analyses on three intercellular networks are conducted by means of statistics. It is proved that these parameters can quantitatively describe the conditions, properties, structures and functions of networks from different perspectives. These wireless communication networks have a hierarchical structure, and demonstrate a certain robustness. Meanwhile, different doses of Cordyceps militaris can change the importance and role of the cells during the wireless communications. The consumption of Cordyceps militaris mainly plays a role in down-regulating the intercellular wireless communication network in vivo. Therefore, Cordyceps militaris has good health protection and anti-inflammatory effect on metabolic syndrome（MS） and cardiovascular or cerebrovascular diseases caused by allergic reaction and overnutrition. The middle dose exerts the greatest effect from an average viewpoint. When further increasing the dose, the functional strength is contrarily lowered down. This shows that Cordyceps militaris at various doses has nonlinear and dual-direction regulatory functions on organisms.