急性ST段抬高型心肌梗死患者入院早期中性粒细胞/淋巴细胞比值与院内主要不良心血管事件的相关性

Relationship Between the Ratio of Neutrophil/Lymphocyte and In-hospital Major Adverse Cardiac Events in Patients With Acute ST-elevation Myocardial Infarction at the Early Admission

目的：探讨急性ST段抬高型心肌梗死（STEM1）患者入院早期中性粒细胞／淋巴细胞比值（NLR）与院内主要不良心血管事件（MACE）的相关性。方法：回顾分析2010—01至2014—12我院接受急诊经皮冠状动脉介入治疗（PCI）的STEMI患者420例，分为发生院内MACE组（n=47）和正常出院组（n=273）。应用单因素及多因素Logistic回归分析评价NLR是否可以作为STEMI患者发生院内MACE的独立危险因素。结果：单因素Logistic回归分析提示：高NLR患者院内MACE发生率明显高于低NLR患者（比值比=3．19，95％可信区间：1．55—2．65，P=0．012）。多因素Logistic回归分析提示：高NLR是STEMI患者发生院内MACE的独立危险因素（比值比=3．05，95％可信区间：1．59～10．54，P=0．015）。结论：入院早期高NLR与STEMI患者发生院内MACE相关，是STEMI患者发生院内MACE的独立危险因素。

Objective： To explore the relationship between the ratio of neutrophil/lymphocyte （NLR） and in-hospital major adverse cardiac events （MACE） in patients with acute ST-elevation myocardial infarction （STEMI） at early admission. Methods： A total of 420 acute STEMI patients admitted and received primary PCI in our hospital from 2010-01 to 2014-12 were retrospectively studied. The patients were divided into 2 groups： In-hospital MACE group, n=47 and Normal discharged group, n=373. Uni- and multivariate analyses were conducted to assess whether high NLR is the independent predictor for in-hospital MACE occurrence. Results： Univariate regression analysis indicated that the occurrence rate of in-hospital MACE in high NLR patients were higher than those in low NLR patients （OR=3.19, 95% CI 1.55-2.65, P=0.012）. Multivariate regression analysis showed that high NLR was the independent risk factor for in-hospital MACE occurrence in STEMI patients （OR=3.05, 95% CI 1.59-10.54, P=0.015）. Conclusion： High NLR is the independent risk factor for in-hospital MACE occurrence in STEMI patients at the early admission.