ADAM33基因多态性与中国汉族人群支气管哮喘相关性的Meta分析

Association between ADAM33 Gene Polymorphisms and Susceptibility to Asthma in Chinese Han Population:A Meta-analysis

目的系统评价解整合素-金属蛋白酶33(ADAM33)基因T2(rs2280090)、S2(rs528557)和V4(rs2787094)位点多态性与中国汉族人群支气管哮喘的相关性。方法计算机检索Pub Med、Web of Science、CNKI、Wan Fang Data和VIP数据库,搜集有关ADAM33基因多态性与中国汉族人群支气管哮喘相关性的病例-对照研究,检索时限均为建库至2014年12月。由两位研究者独立筛选文献、提取资料,并评价纳入研究的偏倚风险后,采用Stata 12.1软件进行Meta分析。结果最终纳入8个病例-对照研究,包括1 651例支气管哮喘患者和1 639例对照。Meta分析结果显示:在总体研究中,ADAM33基因T2多态性与哮喘发病风险降低具有相关性[AA+AG vs.GG:OR=0.316,95%CI(0.151,0.659),P=0.002],S2多态性与哮喘发病风险增加具有相关性[GG+GC vs.CC:OR=1.271,95%CI(1.023,1.578),P=0.030],但V4多态性与哮喘发病风险不具有相关性[GG+GC vs.CC:OR=1.561,95%CI(0.638,3.823),P=0.330]。按照年龄进行的亚组分析结果提示,T2多态性与降低成人和儿童哮喘发病风险均有相关性,S2多态性与增加成人哮喘发病风险具有相关性,但V4多态性与成人和儿童哮喘发病风险均无相关性。结论ADAM33基因T2和S2多态性与中国汉族人群支气管哮喘发病风险具有相关性。受纳入研究的数量和质量的限制,上述结论尚需要更多研究予以证实。

Objective To systematically review the association between ADAM33 （a disintegrin and metalloproteinase domain33） T2 （rs2280090）, S2 （rs528557）, and V4 （rs2787094） polymorphisms and asthma in Chinese Hun population. Methods We electronically searched databases including PubMed, Web of Science, CNKI, WanFang Data and VIP from inception to December 2014, to collect case-control studies about the association between ADAM33 polymorphisms and asthma in Chinese Han population. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using Stata 12.1 software. Results A total of 8 case-control studies including 1 651 asthma patients and 1 639 controls were included. The results of meta-analysis showed that： ADAM33 T2 polymorphism was associated with decreased risk of asthma （AA＋AG vs. GG： OR=0.316, 95%CI 0.151 to 0.659, P=0.002）, and the S2 polymorphism was associated with increased risk of asthma （GG＋GC vs. CC： OR=1.271, 95%CI 1.023 to 1.578, P=0.030）. However, no significant association was found between asthma risk and V4 polymorphism （GG＋GC vs. CC： OR=1.561, 95%CI 0.638 to 3.823, P=0.330）. Subgroup analysis by age indicated that the T2 polymorphism was associated with decreased risk of asthma in both adults and children, the S2 polymorphism was only associated with increased risk of asthma in adults, however, no significant association was found between asthma and the ADAM33 V4 polymorphism in both adults and children subgroups. Conclusion Current evidence shows that the ADAM33 T2 and S2 polymorphisms are associated with risk of asthma in Chinese Hun population. Due to the limited quantity and quality of the studies, the above conclusion still need to be verified by further more high-quality studies.