益气滋阴、活血通络方干预动脉粥样硬化相关炎性因子的表达

Yiqi Ziyin Huoxue Tongluo Prescription Intervenes Expressions of Atherosclerosis Related Inflammatory Cytokines

目的:探讨益气滋阴、活血通络方(简称中药复方)防治动脉粥样硬化的临床疗效及作用机制。方法:将符合诊断标准的150例患者,随机分为阿托伐他汀对照组(30例),中药复方小、中、高剂量观察组(各40例)。治疗0,4,8周后,观察各组颈动脉中内膜厚度(intima media thickness,IMT),白细胞介素-6(interleukin-6,IL-6),肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α),基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)的变化情况。结果:与阿托伐他汀对照组相比较,中药复方小剂量组IMT,IL-6,TNF-α,MMP-9均显著升高(P<0.05),而中药复方中、高剂量组均无显著性差异;中药复方小剂量组组内比较,IMT,IL-6,TNF-α,MMP-9均无显著性差异,中、高剂量组组内比较均有显著性差异(P<0.05)。结论:中药复方具有防治动脉粥样硬化的作用,可能是通过抗炎来完成,且量效、时效分别呈正相关。

Objective： To observe the clinical effect and mechanism of Yiqi Ziyin Huoxue Tongluo prescription（referred to as Chinese medicine compound） in treating atherosclerosis. Method： One hundred and fifty patients which meet the diagnosis standard were randomly divided into atorvastatin group（30 cases）,Chinese medicine compound low（40 cases）,middle（40 cases） and high dose groups（40 cases）. After treating for 0,4,8 weeks,the changes of intima media thickness（IMT）,interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）,and matrix metalloproteinase-9（MMP-9） were compared among the groups. Result： Compared to atorvastatin group,IMT,IL-6,TNF-α,MMP-9 in Chinese medicine compound low dose group were significantly increased（P〈0. 05）,however,there was no significant difference in Chinese medicine compound middle and high dose groups; IMT,IL-6,TNF-α,MMP-9 showed no significant difference within Chinese medicine compound low dose group,but showed significant difference within Chinese medicine compound middle and high dose groups（P〈0. 05）. Conclusion： Chinese medicine compound can prevent and treat atherosclerosis,whose mechanism may be related to anti-inflammatory,and its dose-effect relationship and time-effect relationship are positively correlated respectively.