基于临床诊疗文献的中药防治肥胖症组方及配伍规律研究

Analysis on Composition and Compatibility Principles of Chinese Medicine Can Prevent and Treat Obesity Based on Literature of Clinical Diagnosis and Treatment

目的:分析中药防治肥胖症的组方及配伍规律。方法:依据研究目的,检索中国生物医学文献数据库(CBM),共纳入有效文献167篇。采用人工方式从中医临床诊疗文献中收集与疾病证候、方剂、中药相关信息,运用频数统计、关联规则和复杂网络等分析方法进行中药配伍特点的研究。结果:筛选出临床治疗肥胖症处方209首,确定了前10位常用高频药物。通过关联规则挖掘得到588个中药组合,并初步确定治疗肥胖症的核心药物及基本方。结论:通过分析,提示茯苓、泽泻、白术、山楂为治疗肥胖症的核心药物。治以健脾益气、祛湿化痰为主,并根据不同兼证,酌情配伍具有理气、泻下、活血等功效的药物,以达到标本同治的目的。

Objective： To analyze the composition and compatibility principles of the Chinese medicine that can prevent and treat obesity. Method： The 167 valid references were included after retrieving the Chinese biomedical literature database（CBM） according to the research purpose. We collected the information related to disease syndrome,prescription,and Chinese medicine from clinical treatment of traditional Chinese medicine（TCM） literature by artificial way. Then we analyzed the compatibility characteristics of Chinese medicine using frequency statistics,association rules and complex network analysis methods. Result： We screened out 209 prescriptions for obesity in clinical used,and identified the top ten high-frequency commonly used medicines. 588 Chinese medicinal combinations were obtained by association rules,and the core herbs and basic prescriptions for obesity were determined preliminarily. Conclusion： Poria, Alismatis Rhizoma, Atractylodis Macrocephalae Rhizoma and Crataegi Fructus were core herbs for obesity by analyzing. The mechanism was related to replenishing spleen and Qi,expelling dampness and phlegm,and supplemented with cathartic,Qi-regulating drugs,and blood activating herbs according to actual pathogenic condition to achieve the purpose of curing.