益心舒胶囊辅助治疗冠心病心绞痛有效性的Meta分析

Efficacy of Yixinshu Capsule in the Adjuvant Treatment of Angina Pectoris:A Meta-analysis

目的:系统评价益心舒胶囊辅助治疗冠心病心绞痛的有效性,以为临床提供循证参考。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、Medline和EMBase,收集益心舒胶囊(试验组)对比其他药物(对照组)辅助治疗冠心病心绞痛有效性的随机对照试验(RCT),对符合纳入标准的临床研究进行资料提取,并采用改良后的Jadad量表进行质量评价,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入11项RCT,合计1 827例患者。Meta分析结果显示,试验组患者心绞痛改善总有效率[OR=0.30,95%CI(0.23,0.40),P<0.001]、心电图改善总有效率[OR=0.52,95%CI(0.41,0.66),P<0.001]均显著高于对照组,差异有统计学意义。结论:益心舒胶囊辅助治疗冠心病心绞痛的有效性较好。

OBJECTIVE ： Tosystematically evaluate the efficacy of Yixinshu capsule in the adjuvant treatmentof angina pecto- ris, and provide evidence-based reference for clinical treatment. METHODS： Retrieved from CJFD, VIP Database, Wanfang Database, Medline and EMBase, randomized controlled trials（RCT）about the efficacyof Yixinshu capsule（test group） versus other drugs （control group） in the adjuvant treatment of angina pectoris were collected. Meta-analysis was performed bu using Rev Man 5.2 software after data extraction and quality evaluation by modified Jadad. RESULTS： Totally 11 RCTs were enrolled, involving 1 827 patients. Results of Meta-analysis showed the total effective rate of angina pectoris improvement [OR=0.30,95 % CI （0.23,0.40）, P〈 0.001] and electrocardiogram improvement [OR=0.52,95%CI（0.41,0.66）,P〈0.001] in test group were significantly higher than control group, there was significant difference between 2 groups. CONCLUSIONS： Yixinshu is effective for the adjuvant treatment of angina pectoris.