枸橼酸钾粒剂对低钾血症患者电解质的影响

Effects of potassium citrate granuals on blood electrolyte levels of patients with hypokalemia

目的 比较研究低钾血症患者口服构橼酸钾颗粒剂及 １０％氯化钾口服液后血电解质水平变化。方法 低钾血症患者随机分为构橼酸钾颗粒剂组及氯化钾组，每组１００例，分别口服枸橼酸钾颗粒剂，２包／次（相当于 ２ｇ氯化钾含钾量），每日 ３次，及 １０％氯化钾。服液 ２０ ｍｌ，每日 ３次，应用６天，余治疗相似。用药第４及第６天空腹抽血测定血生化指标。结果 枸橼酸钾颗粒剂具有良好的补钾效果，对低钾血症患者用药３天及６天可使血清钾分别上升０．６５ｍｍｏ１／Ｌ及1．０５ｍｍｏｌ／Ｌ，其补钾疗效优于１０％氯化钾口服液。枸橼酸钾颗粒剂不良反应少且轻微，明显优于１０％氯化钾口服液。结论 枸橼酸钾颗粒剂补钾疗效肯定，临床应用耐受性良好，为理想的口服补钾命剂。

Aim: To observe the changes of electrolyte levels in hypokalemic patients after oral admin-istration of potassium citrate granules and 10% potassium chloride(KCL) aolution. Methods Two hundred hypokalemic patients were randomly assigned into potassium citrate group and KCL group with 100 patients in each group. Patients in different group were given potassium citrate 2 packages tid and 10% KCL solution 20m1 tid, respectively for 6 days, while other therapeutic measures were about the same. Fast serum electrolyte levels and other related biochemical parameters were determined. Results Potassium citrate granules had better potassium replacement effect than KCL solution. Serum potassium level was increased by 0.65 and 1.05 mmol/ L 3 and 6 days after the administration of potassium citrate granules. Potassium citrate granules had less side effects than KCL solution. Conclusions Potassium citrate granules is an ideal potassium replacement agent.