摘要
目的探讨奥沙利铂联合替吉奥方案与XELOX方案(奥沙利铂联合卡培他滨)治疗晚期结直肠癌的疗效及毒副作用。方法将168例晚期结直肠癌患者随机分为2组,对照组患者采用XELOX方案治疗,观察组患者采用奥沙利铂联合替吉奥方案进行治疗。观察对比2组患者化疗后的疗效情况和毒副作用发生情况。结果观察组化疗总有效率(CR+PR)为48.84%,与对照组的51.22%比较,差异无统计学意义(P>0.05)。2组患者化疗后的疾病控制率(DCR)比较差异不明显(P>0.05)。化疗后,2组患者骨髓抑制、胃肠道反应、口腔黏膜病变、神经毒性和肾损伤的发生率比较差异不明显(P>0.05)。观察组患者化疗后手足综合征和肝损伤的发生率均明显高于对照组(P<0.05)。结论奥沙利铂联合替吉奥方案与XELOX方案化疗均可有效治疗晚期结直肠癌,且XELOX方案的不良反应更小,安全性更高,有利于临床治疗。
Objective To study the efficacy and side effects of oxaliplatin combined with Gio program and XELOX program（ oxaliplatin plus capecitabine） for advanced colorectal cancer. Methods 168 cases of patients with advanced colorectal cancer were randomly divided into 2 groups. The control group were treated with XELOX regimen,the observation group were treated with oxaliplatin combined with Gio program. Efficacy of chemotherapy and the occurrence of side effects of the 2 groups were observed and compared. Results Total efficiency（ CR ＋ PR） of the observation group was 48. 84%,which was higher than that of the control group（ 51. 22%）,the difference was not statistically significant（ P〉0. 05）. After chemotherapy,the disease control rate（ DCR） between the 2 groups patients were compared,the difference was not significantly different（ P〉0. 05）. After chemotherapy,the incidence of bone marrow suppression,gastrointestinal reactions,oral mucosal lesions and neurological toxicity and kidney damage between the 2 groups were compared,the difference was not statistically significant（ P〉0. 05）. The incidence of hand-foot syndrome and liver injury of the observation group were higher than those of the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Oxaliplatin combined with Gio program and XELOX chemotherapy for advanced colorectal cancer are effective,and XELOX programs has less adverse reactions,it is safe and conducive to clinical treatment.
出处
《实用癌症杂志》
2016年第1期99-102,共4页
The Practical Journal of Cancer
