节细胞胶质瘤的临床病理分析合并文献复习

Clinicopathologic Analysis of Ganglioglioma and Review of the Literature

目的探讨节细胞胶质瘤的临床病理学特点及诊断要点。方法回顾性分析18例节细胞胶质瘤的临床资料、病理形态学及免疫组化特征,并结合文献对其诊断及鉴别诊断进行探讨。结果节细胞瘤镜下由肿瘤性胶质细胞和发育不良的节细胞组成,伴淋巴细胞浸润。免疫组化:胶质成分表达GFAP、Oligo-2和S-100,节细胞表达Syn、CgA、NeuN和MAP2,Ki-67增殖指数平均3%,部分节细胞胶质瘤CD34阳性。结论节细胞胶质瘤,非常罕见,易与其他肿瘤混淆导致误诊。根据组织学和免疫组织化学特征诊断节细胞胶质瘤至关重要。

Objective To explore the clinicopathologic characteristics and diagnostic criteria of ganglioglioma. Methods Clinical data,morphology and immunohistochemistry characteristics of 18 cases of gangliogliomas were retrospectively studied,and treatment and differential diagnosis were explored combined with literature. Results Ganglioglioma was characterized by a combination of neoplastic glial cell and dysplastic ganglion cells with lymphocytes infiltration. Immunohistochemistry showed that the glia component were GFAP、Oligo-2 and S-100 protein. Nuronally differentiated cells were immunolabeled by Syn、CgA、NeuN and MAP2 protein. The MIB（ Ki-67） labelling index was 3%,part of ganglioglioma revealed positive immunostaining for CD34. Conclusion It is easy to misdiagnose ganglioglioma with other tumors. Accurate diagnosis of ganglioglioma mainly depend on histopathological and immunohistochemical features.