摘要
目的 研究国产右旋普萘洛尔（Ｄ－ｐｒｏｐｒａｎｏｌｏｌ，Ｄ－Ｐ）阴道内给药对家兔和大鼠的耐受性及其对血糖，脂代谢和性激素水平的影响。方法 家兔组：１２ 只家兔分４组，３只予以Ｄ－Ｐ栓剂（每个栓剂含Ｄ－Ｐ ６０ｍｇ和适量的基质聚乙二醇 １０００）阴道内插入给药，每天一次，连续１０天，并与阳性对照组（氯胺），阴性对照组（单纯机械刺激）和基质组（聚乙二醇）作比较；大鼠组：１２只大鼠给予阴道内注入Ｄ－Ｐ ０．２ｍｌ（４０ｍｇ／ｍｌ）每日一次，连续５６天，每２周采血一次，测血糖、血脂和性激素浓度（Ｅ２，Ｐ，ＬＨ，ＦＳＨ）。实验结束后，立即处死动物，解剖阴道，用肉眼和显微镜检查阴道组织受损情况。结果 在家兔组未见阴道组织有异常损害，与正常对照组比较无明显差异（Ｐ＞ ０．０５），大鼠组可见阴道组织有轻微充血、水肿，但均在可耐受评分值内，对血糖血脂和性激素水平均无明显影响。结论 国产Ｄ－Ｐ阴道内给药对家兔和大鼠均无明显影响，说明阴道内给药是安全的。
Aim To study the tolerance of D - propranolol and its effect on sugar, lipid metabolism and sex hormone levels by intravaginal administration in rats and rabbits. Metbods 1. Rabbit group: three rabbits were given D - propranolol suppository (each suppository contain D - propranolol 60mg and opporture amount polyethanediol) by vaginal insertion, q. d. for 10 days. 2. Rat group: 12 rats were given D - propranolol solution (40mg/ml) 0. 2 ml by direct injection into rat vagina q. d. for 56 days and blood samples were collected for measurement of blood sugar, lipids and sex hormone levels every 2 weeks. Immediately af- ter killing all subject animals. Vaginal tissues were examined by macroscopy and mi- croscopy. Results In the rabbits and rats group, no marked lesions of vaginal tissues were observed and the tissues did not significantly differ from those in the control group (P> 0.05) and in rats group were slightly affected, i. e. mucosa edema and /or congestion but all those changes could be tolerated, and there were no changes in blood sugar, lipids and sex hormones after treatmetn with D - propranolol for 8 weeks. Conclusions The results suggested that D - propranolol is safe when used in vagina.
基金
安徽省八五攻关项目
